Complex karyotype in patients with mantle cell lymphoma predicts inferior survival and poor response to intensive induction therapy

Brian Greenwell, Irl; D. Staton, Ashley; J. Lee, Michael; M. Switchenko, Jeffrey; Saxe, Debra; Maly, Joseph; A. Blum, Kristie; S. Grover, Natalie; Mathews, Stephanie; J. Gordon, Max; V. Danilov, Alexey; Epperla, Narendranath; S. Fenske, Timothy; Hamadani, Mehdi; I. Park, Steven; R. Flowers, Christopher; B. Cohen, Jonathon

doi:10.1002/cncr.31328

Public

Complex karyotype in patients with mantle cell lymphoma predicts inferior survival and poor response to intensive induction therapy

Published in Cancer • Mar 26, 2018

Authors:

Irl Brian Greenwell

Ashley D. Staton

Michael J. Lee

Abstract

BACKGROUND: Risk stratification of newly diagnosed patients with mantle cell lymphoma (MCL) primarily is based on the MCL International Prognostic Index (MIPI) and Ki-67 proliferative index. Single-center studies have reported inferior outcomes in patients with a complex karyotype (CK), but this rem...

Subject

Medicine

Mantle cell lymphoma

Hazard ratio

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