Primary Non-Response to Tumor Necrosis Factor Antagonists is Associated with Inferior Response to Second-line Biologics in Patients with Inflammatory Bowel Diseases: A Systematic Review and Meta-analysis

Singh, Siddharth; George, John; S. Boland, Brigid; Vande Casteele, Niels; J. Sandborn, William

doi:10.1093/ecco-jcc/jjy004

Public

Primary Non-Response to Tumor Necrosis Factor Antagonists is Associated with Inferior Response to Second-line Biologics in Patients with Inflammatory Bowel Diseases: A Systematic Review and Meta-analysis

Published in Journal of Crohn s and Colitis • Jan 14, 2018

Authors:

Siddharth Singh

John George

Brigid S. Boland

Abstract

BACKGROUND AND AIMS: We sought to analyze whether response to a second-line biologic varies depending on the reason for discontinuation of the primary anti-TNF agent (primary non-response [PNR], secondary loss of response [LOR] after initial response, or intolerance), through a systematic review and...

Subject

Medicine

Meta-analysis

Inflammatory bowel disease

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