Focal Irradiation and Systemic TGFβ Blockade in Metastatic Breast Cancer

C. Formenti, Silvia; Lee, Percy; Adams, Sylvia; D. Goldberg, Judith; Li, Xiaochun; W. Xie, Mike; A. Ratikan, Josephine; Felix, Carol; Hwang, Lin; F. Faull, Kym; Sayre, James; A. Hurvitz, Sara; A. Glaspy, John; Comı́n-Anduix, Begoña; Demaria, Sandra; Schaue, Dörthe; H. McBride, William

doi:10.1158/1078-0432.ccr-17-3322

Public

Focal Irradiation and Systemic TGFβ Blockade in Metastatic Breast Cancer

Published in Clinical Cancer Research • Feb 23, 2018

Authors:

Silvia C. Formenti

Percy Lee

Sylvia Adams

Abstract

Abstract Purpose: This study examined the feasibility, efficacy (abscopal effect), and immune effects of TGFβ blockade during radiotherapy in metastatic breast cancer patients. Experimental Design: Prospective randomized trial comparing two doses of TGFβ blocking antibody fresolimumab. Metastatic br...

Subject

Medicine

Metastatic breast cancer

Hazard ratio

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