Bioactivity-Based Molecular Networking for the Discovery of Drug Leads in Natural Product Bioassay-Guided Fractionation

Nothias, Louis‐Félix; Nothias-Esposito, Mélissa; Silva, Ricardo; Wang, Mingxun; Protsyuk, Ivan; Zhang, Zheng; Sarvepalli, Abi; Leyssen, Pieter; Touboul, David; Costa, Jean; Paolini, Julien; Alexandrov, Theodore; Litaudon, Marc; C. Dorrestein, Pieter

doi:10.1021/acs.jnatprod.7b00737

Public

Bioactivity-Based Molecular Networking for the Discovery of Drug Leads in Natural Product Bioassay-Guided Fractionation

Published in Journal of Natural Products • Mar 2, 2018

Authors:

Louis‐Félix Nothias

Mélissa Nothias-Esposito

Ricardo Silva

Abstract

It is a common problem in natural product therapeutic lead discovery programs that despite good bioassay results in the initial extract, the active compound(s) may not be isolated during subsequent bioassay-guided purification. Herein, we present the concept of bioactive molecular networking to find...

Subject

Bioassay

Drug discovery

Natural product

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