E2F1 promotes hepatic gluconeogenesis and contributes to hyperglycemia during diabetes

Giralt, Albert; Denechaud, Pierre‐Damien; C. López‐Mejía, Isabel; Delacuisine, Brigitte; Blanchet, Émilie; Bonner, Caroline; Pattou, François; Annicotte, Jean‐Sébastien; Fajas, Lluís

doi:10.1016/j.molmet.2018.02.011

Public

E2F1 promotes hepatic gluconeogenesis and contributes to hyperglycemia during diabetes

Published in Molecular Metabolism • Feb 26, 2018

Authors:

Albert Giralt

Pierre‐Damien Denechaud

Isabel C. López‐Mejía

Abstract

OBJECTIVE: Aberrant hepatic glucose production contributes to the development of hyperglycemia and is a hallmark of type 2 diabetes. In a recent study, we showed that the transcription factor E2F1, a component of the cell cycle machinery, contributes to hepatic steatosis through the transcriptional ...

Subject

Gluconeogenesis

Diabetes mellitus

Endocrinology

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