The invasin D protein from Yersinia pseudotuberculosis selectively binds the Fab region of host antibodies and affects colonization of the intestine

Sadana, Pooja; Geyer, Rebecca; Pezoldt, Joern; Helmsing, Saskia; Huehn, Jochen; Hust, Michael; Dersch, Petra; Scrima, Andrea

doi:10.1074/jbc.ra117.001068

Public

The invasin D protein from Yersinia pseudotuberculosis selectively binds the Fab region of host antibodies and affects colonization of the intestine

Published in Journal of Biological Chemistry • Mar 13, 2018

Authors:

Pooja Sadana

Rebecca Geyer

Joern Pezoldt

Abstract

2-4 days after infection, indicating that InvD is a virulence factor. During infection, InvD was expressed in all parts of the intestinal tract, but not in deeper lymphoid tissues. The crystal structure of the C-terminal adhesion domain of InvD revealed a distinct Ig-related fold that, apart from th...

Subject

Yersinia pseudotuberculosis

Biology

Microbiology

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