Tumor-derived lactate induces M2 macrophage polarization via the activation of the ERK/STAT3 signaling pathway in breast cancer

Mu, Xianmin; Shi, Wei; Xu, Yue; Xu, Che; Zhao, Ting; Geng, Biao; Yang, Jing; Pan, Jinshun; Shi, Hu; Zhang, Chen; Zhang, Juan; Wang, Chao; Shen, Jiajia; Che, Yin; Liu, Zheng; Lv, Yuanfang; Wen, Hao; You, Qiang

doi:10.1080/15384101.2018.1444305

Public

Tumor-derived lactate induces M2 macrophage polarization via the activation of the ERK/STAT3 signaling pathway in breast cancer

Published in Cell Cycle • Feb 16, 2018

Authors:

Xianmin Mu

Wei Shi

Yue Xu

Abstract

Tumor-associated macrophages (TAM) are prominent components of tumor microenvironment (TME) and capable of promoting cancer progression. However, the mechanisms for the formation of M2-like TAMs remain enigmatic. Here, we show that lactate is a pivotal oncometabolite in the TME that drives macrophag...

Subject

MAPK/ERK pathway

Cancer research

Macrophage polarization

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