VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation

Yue, Yanan; Liu, Jun; Liu, Jun; Cui, Xiaolong; Cao, Jie; Luo, Guanzheng; Zhang, Zezhou; Cheng, Tao; Gao, Minsong; Shu, Xiao; Ma, Honghui; Wang, Fengqin; Wang, Xinxia; Shen, Bin; Wang, Yizhen; Feng, Xin‐Hua; He, Chuan; Liu, Jianzhao; Liu, Jianzhao

doi:10.1038/s41421-018-0019-0

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VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation

Published in Cell Discovery • Feb 23, 2018

Authors:

Yanan Yue

Jun Liu

Abstract

Abstract N 6 -methyladenosine (m 6 A) is enriched in 3′untranslated region (3′UTR) and near stop codon of mature polyadenylated mRNAs in mammalian systems and has regulatory roles in eukaryotic mRNA transcriptome switch. Significantly, the mechanism for this modification preference remains unknown, ...

Subject

Polyadenylation

Three prime untranslated region

Untranslated region

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