Atlas of the Immune Cell Repertoire in Mouse Atherosclerosis Defined by Single-Cell RNA-Sequencing and Mass Cytometry

Winkels, Holger; Ehinger, Erik; Vassallo, Melanie; Buscher, Konrad; Q. Dinh, Huy; Kobiyama, Kouji; A.J. Hamers, Anouk; Cochain, Clément; Vafadarnejad, Ehsan; Saliba, Antoine‐Emmanuel; Zernecke, Alma; Bala Pramod, Akula; Ghosh, Amlan; Anto Michel, Nathaly; Hoppe, Natalie; Hilgendorf, Ingo; Zirlik, Andreas; C. Hedrick, Catherine; Ley, Klaus; Wolf, Dennis

doi:10.1161/circresaha.117.312513

Public

Atlas of the Immune Cell Repertoire in Mouse Atherosclerosis Defined by Single-Cell RNA-Sequencing and Mass Cytometry

Published in Circulation Research • Mar 15, 2018

Authors:

Holger Winkels

Erik Ehinger

Melanie Vassallo

Abstract

Rationale: Atherosclerosis is a chronic inflammatory disease that is driven by the interplay of pro- and anti-inflammatory leukocytes in the aorta. Yet, the phenotypic and transcriptional diversity of aortic leukocytes is poorly understood. Objective: We characterized leukocytes from healthy and ath...

Subject

Mass cytometry

Biology

Flow cytometry

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