FOXO1 regulates VEGFA expression and promotes angiogenesis in healing wounds

Helen Jeon, Hyeran; Yu, Quan; Lu, Yongjian; Spencer, Evelyn; Lu, Chanyi; N. Milovanova, Tatyana; Yang, Yang; Zhang, Chenying; Stepanchenko, Olga; P. Vafa, Rameen; G. Coelho, Paulo; T. Graves, Dana

doi:10.1002/path.5075

Public

FOXO1 regulates VEGFA expression and promotes angiogenesis in healing wounds

Published in The Journal of Pathology • Mar 25, 2018

Authors:

Hyeran Helen Jeon

Quan Yu

Yongjian Lu

Abstract

Angiogenesis is a critical aspect of wound healing. We investigated the role of keratinocytes in promoting angiogenesis in mice with lineage-specific deletion of the transcription factor FOXO1. The results indicate that keratinocyte-specific deletion of Foxo1 reduces VEGFA expression in mucosal and ...

Subject

Angiogenesis

FOXO1

Wound healing

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