Antifungal Combinations for Treatment of Cryptococcal Meningitis in Africa

F. Molloy, Síle; Kanyama, Cecilia; S. Heyderman, Robert; Loyse, Angela; Kouanfack, Charles; Chanda, Duncan; Mfinanga, Sayoki; Temfack, Elvis; Lakhi, Shabir; Lesikari, Sokoine; K Chan, Adrienne; Stone, Neil; Kalata, Newton; Karunaharan, Natasha; Gaskell, Kate; Peirse, Mary; Ellis, Jayne; Chawinga, Chimwemwe; Sa’a Lontsi, Sandrine; Ndong, Jean-Gilbert; Bright, Philip; Lupiya, Duncan; Chen, Tao; Bradley, John; Adams, Jack; van der Horst, Charles; J. van Oosterhout, Joep; Sini, Victor; Njankouo Mapoure, Yacouba; Mwaba, Peter; Bicanic, Tihana; G. Lalloo, David; Wang, Duolao; C. Hosseinipour, Mina; Lortholary, Olivier; Jaffar, Shabbar; S. Harrison, Thomas

doi:10.1056/nejmoa1710922

Public

Antifungal Combinations for Treatment of Cryptococcal Meningitis in Africa

Published in New England Journal of Medicine • Mar 14, 2018

Authors:

Síle F. Molloy

Cecilia Kanyama

Robert S. Heyderman

Abstract

BACKGROUND: Cryptococcal meningitis accounts for more than 100,000 human immunodeficiency virus (HIV)-related deaths per year. We tested two treatment strategies that could be more sustainable in Africa than the standard of 2 weeks of amphotericin B plus flucytosine and more effective than the widel...

Subject

Cryptococcal meningitis

Antifungal

Cryptococcosis

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