Treatment-Free Remission After Second-Line Nilotinib Treatment in Patients With Chronic Myeloid Leukemia in Chronic Phase

Mahon, François-Xavier; Boquimpani, Carla; Kim, Dong‐Wook; Benyamini, Noam; Cristina D. Clementino, Nelma; Shuvaev, Vasily; Ailawadhi, Sikander; H. Lipton, Jeffrey; Turkina, Anna; de Paz, Raquel; Moiraghi, Beatriz; E. Nicolini, Franck; Dengler, Jolanta; Sacha, Tomasz; Takahashi, Naoto; Fellague-Chebra, Rafik; Acharya, Sandip; Wong, Stephane; Jin, Yu; P. Hughes, Timothy

doi:10.7326/m17-1094

Public

Treatment-Free Remission After Second-Line Nilotinib Treatment in Patients With Chronic Myeloid Leukemia in Chronic Phase

Published in Annals of Internal Medicine • Feb 19, 2018

Authors:

François-Xavier Mahon

Carla Boquimpani

Dong‐Wook Kim

Abstract

Background: Treatment-free remission (TFR)-that is, stopping tyrosine kinase inhibitor (TKI) therapy without loss of response-is an emerging treatment goal in chronic myeloid leukemia (CML). Objective: To evaluate TFR after discontinuation of second-line nilotinib therapy. Design: Single-group, phas...

Subject

Nilotinib

Medicine

Myeloid leukemia

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