Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2

Incio, João; A. Ligibel, Jennifer; T. McManus, Daniel; Suboj, Priya; Jung, Keehoon; Kawaguchi, Kosuke; Pinter, Matthias; Babykutty, Suboj; M. Chin, Shan; D. Vardam, Trupti; Huang, Yuhui; N. Rahbari, Nuh; Roberge, Sylvie; Wang, Dannie; L. Gomes‐Santos, Igor; B. Puchner, Stefan; L. Schlett, Christopher; Hoffmman, Udo; Ancukiewicz, Marek; M. Tolaney, Sara; E. Krop, Ian; G. Duda, Dan; Boucher, Yves; Fukumura, Dai; K. Jain, Rakesh

doi:10.1126/scitranslmed.aag0945

Public

Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2

Published in Science Translational Medicine • Mar 14, 2018

Authors:

João Incio

Jennifer A. Ligibel

Daniel T. McManus

Abstract

Anti-vascular endothelial growth factor (VEGF) therapy has failed to improve survival in patients with breast cancer (BC). Potential mechanisms of resistance to anti-VEGF therapy include the up-regulation of alternative angiogenic and proinflammatory factors. Obesity is associated with hypoxic adipo...

Subject

Angiogenesis

Medicine

Adipose tissue

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