Genetic predisposition in anti‐LGI1 and anti‐NMDA receptor encephalitis

H. Mueller, Stefanie; Färber, Anna; Prüß, Harald; Melzer, Nico; S. Golombeck, Kristin; Kümpfel, Tania; Thaler, Franziska; Elišák, Martin; Lewerenz, Jan; Kaufmann, Max; Sühs, Kurt‐Wolfram; Ringelstein, Marius; Kellinghaus, Christoph; G. Bien, Christian; Kraft, Andrea; K. Zettl, Uwe; Ehrlich, Sven; Handreka, Robert; Rostásy, Kevin; Then Bergh, Florian; Faiss, Jürgen; Lieb, Wolfgang; Franke, Andre; Kuhlenbäumer, Gregor; Wandinger, Klaus‐Peter; Leypoldt, Frank

doi:10.1002/ana.25216

Public

Genetic predisposition in anti‐LGI1 and anti‐NMDA receptor encephalitis

Published in Annals of Neurology • Mar 23, 2018

Authors:

Stefanie H. Mueller

Anna Färber

Harald Prüß

Abstract

We performed a genome‐wide association study in 1,194 controls and 150 patients with anti‐ N ‐methyl‐D‐aspartate receptor (anti‐NMDAR, n = 96) or anti‐leucine‐rich glioma‐inactivated1 (anti‐LGI1, n = 54) autoimmune encephalitis. Anti‐LGI1 encephalitis was highly associated with 27 single‐nucleotide ...

Subject

Single-nucleotide polymorphism

Encephalitis

Autoimmune encephalitis

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