Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors

George, Julie; Walter, Vonn; Peifer, Martin; B. Alexandrov, Ludmil; Seidel, Danila; Leenders, Frauke; Maas, Lukas; Müller, Christian; Dahmen, Ilona; M. Delhomme, Tiffany; Ardin, Maude; Leblay, Noémie; Byrnes, Graham; Sun, Ruping; de Reyniès, Aurélien; McLeer‐Florin, Anne; Bosco, Graziella; Malchers, Florian; Menon, Roopika; Altmüller, Janine; Becker, Christian; Nürnberg, Peter; Achter, Viktor; Lang, Ulrich; M. Schneider, Peter; Bogus, Magdalena; G. Soloway, Matthew; D. Wilkerson, Matthew; Cun, Yupeng; McKay, James; Moro‐Sibilot, Denis; Brambilla, Christian; Lantuéjoul, Sylvie; Lemaître, Nicolas; Soltermann, Alex; Weder, Walter; Tischler, Verena; Terje Brustugun, Odd; Lund‐Iversen, Marius; Helland, Åslaug; Solberg, Steinar; Ansén, Sascha; Wright, Gavin; Solomon, Benjamin; Roz, Luca; Pastorino, Ugo; Petersen, Iver; H. Clement, Joachim; Sänger, Jörg; Wolf, Jürgen; Vingron, Martin; Zander, Thomas; Perner, Sven; D. Travis, William; A. Haas, Stefan; Olivier, Magali; Foll, Matthieu; Büttner, Reinhard; Neil Hayes, D.; Brambilla, Élisabeth; Fernandez‐Cuesta, Lynnette; K. Thomas, Roman

doi:10.1038/s41467-018-03099-x

Public

Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors

Published in Nature Communications • Mar 7, 2018

Authors:

Julie George

Vonn Walter

Martin Peifer

Abstract

Abstract Pulmonary large-cell neuroendocrine carcinomas (LCNECs) have similarities with other lung cancers, but their precise relationship has remained unclear. Here we perform a comprehensive genomic ( n = 60) and transcriptomic ( n = 69) analysis of 75 LCNECs and identify two molecular subgroups: ...

Subject

Neuroendocrine tumors

Transcriptome

Biology

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