ATR-Chk1 activation mitigates replication stress caused by mismatch repair-dependent processing of DNA damage

Significance Mismatch repair pathway (MMR)-mediated mismatch correction has largely been recapitulated in the test tube using mismatch-containing DNA substrates. However, a long-standing question remains: How does MMR respond to Me G/T mismatches caused by alkylation damage, and does this affect cel... View More