Tamoxifen enhances stemness and promotes metastasis of ERα36<sup>+</sup> breast cancer by upregulating ALDH1A1 in cancer cells.

Q, Wang; J, Jiang; G, Ying; XQ, Xie; X, Zhang; W, Xu; X, Zhang; E, Song; H, Bu; YF, Ping; XH, Yao; B, Wang; S, Xu; ZX, Yan; Y, Tai; B, Hu; X, Qi; YX, Wang; ZC, He; Y, Wang; JM, Wang; YH, Cui; F, Chen; K, Meng; Z, Wang; XW, Bian

doi:10.1038/cr.2018.15

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Tamoxifen enhances stemness and promotes metastasis of ERα36+ breast cancer by upregulating ALDH1A1 in cancer cells.

Shared by NobleBlocks on Feb 2, 2018 • 12:00 AM UTC

Authors:

Wang Q

Jiang J

Ying G

Abstract

The 66 kDa estrogen receptor alpha (ERα66) is the main molecular target for endocrine therapy such as tamoxifen treatment. However, many patients develop resistance with unclear mechanisms. In a large cohort study of breast cancer patients who underwent surgery followed by tamoxifen treatment, we de...

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