Characterization of DNA ADP-ribosyltransferase activities of PARP2 and PARP3: new insights into DNA ADP-ribosylation

Zarkovic, Gabriella; A. Belousova, E.; Talhaoui, Ibtissam; Saint‐Pierre, Christine; M. Kutuzov, Mikhail; Matkarimov, Bakhyt; Biard, Denis; Gasparutto, Didier; I. Lavrik, Olga; A. Ishchenko, Alexander

doi:10.1093/nar/gkx1318

Public

Characterization of DNA ADP-ribosyltransferase activities of PARP2 and PARP3: new insights into DNA ADP-ribosylation

Published in Nucleic Acids Research • Dec 28, 2017

Authors:

Gabriella Zarkovic

E. A. Belousova

Ibtissam Talhaoui

Abstract

Poly(ADP-ribose) polymerases (PARPs) act as DNA break sensors and catalyze the synthesis of polymers of ADP-ribose (PAR) covalently attached to acceptor proteins at DNA damage sites. It has been demonstrated that both mammalian PARP1 and PARP2 PARylate double-strand break termini in DNA oligonucleot...

Subject

Biology

DNA

DNA damage

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!