Simultaneous Fenton‐like Ion Delivery and Glutathione Depletion by MnO 2 ‐Based Nanoagent to Enhance Chemodynamic Therapy

Lin, Lisen; Song, Jibin; Song, Liang; Ke, Kaimei; Liu, Yijing; Zhou, Zijian; Shen, Zheyu; Li, Juan; Yáng, Zhèn; Tang, Wei; Niu, Gang; Yang, Huanghao; Chen, Xiaoyuan

doi:10.1002/anie.201712027

Public

Simultaneous Fenton‐like Ion Delivery and Glutathione Depletion by MnO 2 ‐Based Nanoagent to Enhance Chemodynamic Therapy

Published in Angewandte Chemie International Edition • Feb 27, 2018

Authors:

Lisen Lin

Jibin Song

Liang Song

Abstract

Abstract Chemodynamic therapy (CDT) utilizes iron‐initiated Fenton chemistry to destroy tumor cells by converting endogenous H 2 O 2 into the highly toxic hydroxyl radical ( . OH). There is a paucity of Fenton‐like metal‐based CDT agents. Intracellular glutathione (GSH) with . OH scavenging ability ...

Subject

Glutathione

Hydroxyl radical

Redox

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