Whole-Genome Sequencing of Pharmacogenetic Drug Response in Racially Diverse Children with Asthma

C. Y. Mak, Angel; J. White, Marquitta; L. Eckalbar, Walter; A. Szpiech, Zachary; S. Oh, Sam; Pino‐Yanes, Maria; Hu, Donglei; C. Goddard, Pagé; Huntsman, Scott; Galanter, Joshua; Chen Wu, Ann; E. Himes, Blanca; Germer, Søren; Moore Vogel, Julia; Bunting, Karen; Eng, Celeste; Salazar, Sandra; L. Keys, Kevin; Liberto, Jennifer; J. Nuckton, Thomas; Nguyen, Thomas; G. Torgerson, Dara; Kwok, Pui–Yan; M. Levin, Albert; C. Celedón, Juan; Forno, Erick; Håkonarson, Håkon; Sleiman, Patrick; Dahlin, Amber; G. Tantisira, Kelan; T. Weiss, Scott; Serebrisky, Denise; Brigino-Buenaventura, Emerita; J. Farber, Harold; Meade, Kelley; A. LeNoir, Michael; C. Avila, Pedro; Sen, Śaunak; Thyne, Shannon; Rodríguez-Cintrón, William; A. Winkler, Cheryl; Moreno‐Estrada, Andrés; Sandoval, Karla; Rodríguez‐Santana, José; Kumar, Rajesh; Keoki Williams, L.; Ahituv, Nadav; Ziv, Elad; A. Seibold, Max; B. Darnell, Robert; Zaitlen, Noah; D. Hernandez, Ryan; G. Burchard, Esteban

doi:10.1164/rccm.201712-2529oc

Public

Whole-Genome Sequencing of Pharmacogenetic Drug Response in Racially Diverse Children with Asthma

Published in American Journal of Respiratory and Critical Care Medicine • Mar 6, 2018

Authors:

Angel C. Y. Mak

Marquitta J. White

Walter L. Eckalbar

Abstract

RATIONALE: Albuterol, a bronchodilator medication, is the first-line therapy for asthma worldwide. There are significant racial/ethnic differences in albuterol drug response. OBJECTIVES: To identify genetic variants important for bronchodilator drug response (BDR) in racially diverse children. METHO...

Subject

Medicine

Pharmacogenetics

Drug response

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