Space microgravity drives transdifferentiation of human bone marrow‐derived mesenchymal stem cells from osteogenesis to adipogenesis

Zhang, Cui; Li, Liang; Jiang, Yuanda; Wang, Cuicui; Geng, Baoming; Wang, Yanqiu; Chen, Jianling; Liu, Fei; Qiu, Peng; Zhai, Guang-Jie; Chen, Ping; Quan, Renfu; Wang, Jinfu

doi:10.1096/fj.201700208rr

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Space microgravity drives transdifferentiation of human bone marrow‐derived mesenchymal stem cells from osteogenesis to adipogenesis

Published in The FASEB Journal • Mar 13, 2018

Authors:

Cui Zhang

Liang Li

Yuanda Jiang

Abstract

Bone formation is linked with osteogenic differentiation of mesenchymal stem cells (MSCs) in the bone marrow. Microgravity in spaceflight is known to reduce bone formation. In this study, we used a real microgravity environment of the SJ-10 Recoverable Scientific Satellite to examine the effects of ...

Subject

Transdifferentiation

Adipogenesis

Mesenchymal stem cell

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