Guanosine tetra- and pentaphosphate increase antibiotic tolerance by reducing reactive oxygen species production in Vibrio cholerae

Young Kim, Hwa; Go, Junhyeok; Lee, Kang‐Mu; Taek Oh, Young; Sun Yoon, Sang

doi:10.1074/jbc.ra117.000383

Public

Guanosine tetra- and pentaphosphate increase antibiotic tolerance by reducing reactive oxygen species production in Vibrio cholerae

Published in Journal of Biological Chemistry • Feb 23, 2018

Authors:

Hwa Young Kim

Junhyeok Go

Kang‐Mu Lee

Abstract

The pathogen Vibrio cholerae is the causative agent of cholera. Emergence of antibiotic-resistant V. cholerae strains is increasing, but the underlying mechanisms remain unclear. Herein, we report that the stringent response regulator and stress alarmone guanosine tetra- and pentaphosphate ((p)ppGpp...

Subject

Vibrio cholerae

Guanosine

Reactive oxygen species

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