Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles

Ricklefs, Franz; A. Alayo, Quazim; Krenzlin, Harald; Bakur Mahmoud, Ahmad; C. Speranza, Maria; Nakashima, Hiroshi; Hayes, Josie; Lee, Kyungheon; Balaj, Leonora; Passaro, Carmela; K. Rooj, Arun; Krasemann, Susanne; S. Carter, Bob; C. Chen, Clark; Steed, Tyler; M. Treiber, Jeffrey; J. Rodig, Scott; S. Yang, Katherine; Nakano, Ichiro; Lee, Hakho; Weissleder, Ralph; O. Breakefield, Xandra; Godlewski, Jakub; Westphal, Manfred; Lamszus, Katrin; J. Freeman, Gordon; Bronisz, Agnieszka; Lawler, Sean; Antonio Chiocca, E.

doi:10.1126/sciadv.aar2766

Public

Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles

Published in Science Advances • Mar 2, 2018

Authors:

Franz Ricklefs

Quazim A. Alayo

Harald Krenzlin

Abstract

. These results suggest that PD-L1 on EVs may be another mechanism for glioblastoma to suppress antitumor immunity and support the potential of EVs as biomarkers in tumor patients.

Subject

Evasion (ethics)

Immune system

Glioblastoma

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