Molecular Classification of Grade 3 Endometrioid Endometrial Cancers Identifies Distinct Prognostic Subgroups

Bosse, Tjalling; A. Nout, Remi; N. McAlpine, Jessica; K. McConechy, Melissa; Britton, Heidi; R. Hussein, Yaser; Gonzalez, Carlene; Ganesan, Raji; C. Steele, Jane; T. Harrison, Beth; Oliva, Esther; Vidal, August; Matias-Guiu, Xavier; R. Abu-Rustum, Nadeem; A. Levine, Douglas; Blake Gilks, C.; A. Soslow, Robert

doi:10.1097/pas.0000000000001020

Public

Molecular Classification of Grade 3 Endometrioid Endometrial Cancers Identifies Distinct Prognostic Subgroups

Shared by NobleBlocks on May 1, 2018 • 12:00 AM UTC

Authors:

Tjalling Bosse

Remi A. Nout

Jessica N. McAlpine

Abstract

Our aim was to investigate whether molecular classification can be used to refine prognosis in grade 3 endometrial endometrioid carcinomas (EECs). Grade 3 EECs were classified into 4 subgroups: p53 abnormal, based on mutant-like immunostaining (p53abn); MMR deficient, based on loss of mismatch repai...

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