Hydrocortisone plus Fludrocortisone for Adults with Septic Shock

Annane, Djillali; Renault, Alain; Brun‐Buisson, Christian; Mégarbane, Bruno; Quenot, Jean‐Pierre; Siami, Shidasp; Cariou, Alain; Forceville, Xavier; Schwebel, Carole; Martin, Claude; Timsit, Jean‐François; Misset, Benoît; Ali Benali, Mohamed; Colin, Gwenhaël; Souweine, Bertrand; Asehnoune, Karim; Mercier, Emmanuelle; Chimot, Loïc; Charpentier, Claire; François, Bruno; Boulain, Thierry; Petitpas, Franck; Constantin, Jean‐Michel; Dhonneur, Gilles; Baudin, François; Combes, Alain; Bohé, Julien; Loriferne, Jean-François; Amathieu, Roland; Cook, Fabrice; Slama, Michel; Leroy, O.; Capellier, Gilles; Dargent, Auguste; Hissem, Tarik; Maxime, Virginie; Bellissant, Éric

doi:10.1056/nejmoa1705716

Public

Hydrocortisone plus Fludrocortisone for Adults with Septic Shock

Published in New England Journal of Medicine • Feb 28, 2018

Authors:

Djillali Annane

Alain Renault

Christian Brun‐Buisson

Abstract

BACKGROUND: Septic shock is characterized by dysregulation of the host response to infection, with circulatory, cellular, and metabolic abnormalities. We hypothesized that therapy with hydrocortisone plus fludrocortisone or with drotrecogin alfa (activated), which can modulate the host response, wou...

Subject

Fludrocortisone

Septic shock

Hydrocortisone

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