Long Terminal Repeat CRISPR-CAR-Coupled "Universal" T Cells Mediate Potent Anti-leukemic Effects.

C, Georgiadis; R, Preece; L, Nickolay; A, Etuk; A, Petrova; D, Ladon; A, Danyi; N, Humphryes-Kirilov; A, Ajetunmobi; D, Kim; JS, Kim; W, Qasim

doi:10.1016/j.ymthe.2018.02.025

Public

Long Terminal Repeat CRISPR-CAR-Coupled "Universal" T Cells Mediate Potent Anti-leukemic Effects.

Shared by NobleBlocks on Mar 6, 2018 • 12:00 AM UTC

Authors:

Georgiadis C

Preece R

Nickolay L

Abstract

Gene editing can be used to overcome allo-recognition, which otherwise limits allogeneic T cell therapies. Initial proof-of-concept applications have included generation of such "universal" T cells expressing chimeric antigen receptors (CARs) against CD19 target antigens combined with transient expr...

Subject

B-all

Crispr/cas9 Gene Editing

Car T cells

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