Interferon gamma, an important marker of response to immune checkpoint blockade in non-small cell lung cancer and melanoma patients

Karachaliou, Niki; González‐Cao, María; Crespo, Guillermo; Drozdowskyj, Ana; Aldeguer, Erika; Giménez‐Capitán, Ana; Teixidó, Cristina; Ángel Molina‐Vila, Miguel; Viteri, Santiago; de los Llanos Gil, María; Martín‐Algarra, Salvador; Pérez-Ruiz, Elísabeth; Márquez‐Rodas, Iván; Rodríguez‐Abreu, Delvys; Blanco, Remedios; Puértolas, Teresa; Angeles Royo, Maria; Rosell, Rafael

doi:10.1177/1758834017749748

Public

Interferon gamma, an important marker of response to immune checkpoint blockade in non-small cell lung cancer and melanoma patients

Published in Therapeutic Advances in Medical Oncology • Jan 1, 2018

Authors:

Niki Karachaliou

María González‐Cao

Guillermo Crespo

Abstract

Background: Programmed death-ligand 1 (PD-L1) may be induced by oncogenic signals or can be upregulated via interferon gamma (IFN-γ). We have explored whether the expression of IFNG, the gene encoding IFN-γ, is associated with clinical response to the immune checkpoint blockade in non-small cell lun...

Subject

Medicine

Lung cancer

Blockade

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