Altered bile acid profile associates with cognitive impairment in Alzheimer's disease—An emerging role for gut microbiome

MahmoudianDehkordi, Siamak; Arnold, Matthias; Nho, Kwangsik; Ahmad, Shahzad; Jia, Wei; Xie, Guoxiang; Louie, Gregory; Kueider‐Paisley, Alexandra; Arthur Moseley, M.; M. Thompson, Paul; St John Williams, Lisa; D. Tenenbaum, Jessica; Blach, Colette; Baillie, Rebecca; Han, Xianlin; Bhattacharyya, Sudeepa; B. Toledo, Jon; Schafferer, Simon; Klein, Sebastian; Koal, Therese; L. Risacher, Shannon; A. Kling, Mitchel; A. Motsinger‐Reif, Alison; M. Rotroff, Daniel; Jack, John; Hankemeier, Thomas; A. Bennett, David; L. De Jager, Philip; Q. Trojanowski, John; M. Shaw, Leslie; W. Weiner, Michael; Murali Doraiswamy, P.; M. van Duijn, Cornelia; J. Saykin, Andrew; Kastenmüller, Gabi; Kaddurah‐Daouk, Rima

doi:10.1016/j.jalz.2018.07.217

Public

Altered bile acid profile associates with cognitive impairment in Alzheimer's disease—An emerging role for gut microbiome

Published in Alzheimer s & Dementia • Oct 15, 2018

Authors:

Siamak MahmoudianDehkordi

Matthias Arnold

Kwangsik Nho

Abstract

INTRODUCTION: Increasing evidence suggests a role for the gut microbiome in central nervous system disorders and a specific role for the gut-brain axis in neurodegeneration. Bile acids (BAs), products of cholesterol metabolism and clearance, are produced in the liver and are further metabolized by g...

Subject

Deoxycholic acid

Cognitive decline

Bile acid

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!