Variance component analysis to assess protein quantification in biomarker validation: application to selected reaction monitoring-mass spectrometry

Klich, Amna; Mercier, Catherine; Gerfault, Laurent; Grangeat, Pierre; Beaulieu, Corinne; Degout-Charmette, Elodie; Fortin, Tanguy; Mahé, Pierre; Giovannelli, Jean‐François; Charrier, Jean‐Philippe; Giremus, Audrey; Maucort‐Boulch, Delphine; Roy, Pascal

doi:10.1186/s12859-018-2075-8

Public

Variance component analysis to assess protein quantification in biomarker validation: application to selected reaction monitoring-mass spectrometry

Published in BMC Bioinformatics • Feb 28, 2018

Authors:

Amna Klich

Catherine Mercier

Laurent Gerfault

Abstract

BACKGROUND: In the field of biomarker validation with mass spectrometry, controlling the technical variability is a critical issue. In selected reaction monitoring (SRM) measurements, this issue provides the opportunity of using variance component analysis to distinguish various sources of variabili...

Subject

Variance (accounting)

Component (thermodynamics)

Statistics

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