Sodium Butyrate Inhibits Inflammation and Maintains Epithelium Barrier Integrity in a TNBS-induced Inflammatory Bowel Disease Mice Model

Chen, Guangxin; Ran, Xin; Li, Bai; Li, Yuhang; He, Dewei; Huang, Bingxu; Fu, Shoupeng; Liu, Juxiong; Wang, Wei

doi:10.1016/j.ebiom.2018.03.030

Public

Sodium Butyrate Inhibits Inflammation and Maintains Epithelium Barrier Integrity in a TNBS-induced Inflammatory Bowel Disease Mice Model

Published in EBioMedicine • Mar 28, 2018

Authors:

Guangxin Chen

Xin Ran

Bai Li

Abstract

G Protein Coupled Receptor 109A (GPR109A), which belongs to the G protein coupled receptor family, can be activated by niacin, butyrate, and -hydroxybutyric acid. Here, we assessed the anti-inflammatory activity of sodium butyrate (SB) on 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis mi...

Subject

Inflammation

Inflammatory bowel disease

Epithelium

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