Association of Placebo, Indomethacin, Ibuprofen, and Acetaminophen With Closure of Hemodynamically Significant Patent Ductus Arteriosus in Preterm Infants

Mitra, Souvik; D. Flórez, Iván; Tamayo, María; Mbuagbaw, Lawrence; Vanniyasingam, Thuva; Angeliki Veroniki, Areti; M. Zea, Adriana; Zhang, Yuan; Sadeghirad, Behnam; Thabane, Lehana

doi:10.1001/jama.2018.1896

Public

Association of Placebo, Indomethacin, Ibuprofen, and Acetaminophen With Closure of Hemodynamically Significant Patent Ductus Arteriosus in Preterm Infants

Published in JAMA • Mar 27, 2018

Authors:

Souvik Mitra

Iván D. Flórez

María Tamayo

Abstract

Importance: Despite increasing emphasis on conservative management of patent ductus arteriosus (PDA) in preterm infants, different pharmacotherapeutic interventions are used to treat those developing a hemodynamically significant PDA. Objectives: To estimate the relative likelihood of hemodynamicall...

Subject

Medicine

Odds ratio

Ductus arteriosus

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