Negative association of antibiotics on clinical activity of immune checkpoint inhibitors in patients with advanced renal cell and non-small-cell lung cancer

Derosa, Lisa; D. Hellmann, Matthew; Spaziano, Marco; Halpenny, Darragh; Fidelle, Marine; Rizvi, Hira; M. Long, Niamh; J. Plodkowski, Andrew; C. Arbour, Kathryn; E. Chaft, Jamie; Rouche, J.A.; Zitvogel, Laurence; Zalcman, Gérard; Albigès, Laurence; Escudier, Bernard; Routy, Bertrand

doi:10.1093/annonc/mdy103

Public

Negative association of antibiotics on clinical activity of immune checkpoint inhibitors in patients with advanced renal cell and non-small-cell lung cancer

Published in Annals of Oncology • Mar 29, 2018

Authors:

Lisa Derosa

Matthew D. Hellmann

Marco Spaziano

Abstract

Background: The composition of gut microbiota affects antitumor immune responses, preclinical and clinical outcome following immune checkpoint inhibitors (ICI) in cancer. Antibiotics (ATB) alter gut microbiota diversity and composition leading to dysbiosis, which may affect effectiveness of ICI. Pat...

Subject

Medicine

Internal medicine

Hazard ratio

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