A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers

C. Berger, Ashton; Korkut, Anil; S. Kanchi, Rupa; M. Hegde, Apurva; F. Lenoir, Walter; Liu, Wenbin; Liu, Yuexin; Fan, Huihui; Shen, Hui; Ravikumar, Visweswaran; Rao, Arvind; Schultz, André; Li, Xubin; Sumazin, Pavel; Williams, Cecilia; Mestdagh, Pieter; H. Gunaratne, Preethi; Yau, Christina; Bowlby, Reanne; Gordon Robertson, A.; Guimarães Tiezzi, Daniel; Wang, Chen; D. Cherniack, Andrew; K. Godwin, Andrew; M. Kuderer, Nicole; S. Rader, Janet; E. Zuna, Rosemary; K. Sood, Anil; J. Lazar, Alexander; I. Ojesina, Akinyemi; Adebamowo, Clement; N. Adebamowo, Sally; Baggerly, Keith; Chen, Ting-Wen; Chiu, Hua‐Sheng; Lefever, Steve; Liu, Liang; L. MacKenzie, Karen; Oršulić, Sandra; Roszik, Jason; Simon Shelley, Carl; Song, Qianqian; P. Vellano, Christopher; Wentzensen, Nicolas; Johnson, Rory; A. Demchok, John; Felau, Ina; Kasapi, Melpomeni; L. Ferguson, Martin; M. Hutter, Carolyn; J. Sofia, Heidi; Tarnuzzer, Roy; Wang, Zhining; Yang, Liming; C. Zenklusen, Jean; Zhang, Jiashan; Chudamani, Sudha; Liu, Jia; Lolla, Laxmi; Naresh, Rashi; Pihl, Todd; Sun, Qiang; Wan, Yunhu; Wu, Ye; Cho, Juok; Defreitas, Timothy; Frazer, Scott; Gehlenborg, Nils; Getz, Gad; I. Heiman, David; Kim, Jaegil; S. Lawrence, Michael; Lin, Pei; Meier, Sam; S. Noble, Michael; Saksena, Gordon; Voet, Doug; Zhang, Hailei; Bernard, Brady; Chambwe, Nyasha; Dhankani, Varsha; Knijnenburg, Theo; Kramer, Roger; Leinonen, Kalle; Liu, Yuexin; Miller, Michael; M. Reynolds, Sheila; Shmulevich, Ilya; Thórsson, Vésteinn; Zhang, Wei; Akbani, Rehan; M. Broom, Bradley; M. Hegde, Apurva; Ju, Zhenlin; S. Kanchi, Rupa; Korkut, Anil; Li, Jun; Liang, Han; Ling, Shiyun; Liu, Wenbin; Lu, Yiling; B. Mills, Gordon; Ng, Kwok-Shing; Rao, Arvind; P. Ryan, Michael; Wang, Jing; N. Weinstein, John; Zhang, Jiexin; Abeshouse, Adam; Armenia, Joshua; Chakravarty, Debyani; K. Chatila, Walid; de Bruijn, Ino; Gao, Jianjiong; Groß, Benjamin; Heins, Zachary; Kundra, Ritika; La, Konnor; Ladanyi, Marc; Luna, Augustin; G. Nissan, Moriah; Ochoa, Angelica; Phillips, Sarah; Reznik, Ed; Sánchez-Vega, Francisco; Sander, Chris; Schultz, Nikolaus; E. Sheridan, Robert; Onur Sumer, S.; Sun, Yichao; S. Taylor, Barry; Wang, Jioajiao; Zhang, Hongxin; Anur, Pavana; Peto, Myron; T. Spellman, Paul; C. Benz, Christopher; M. Stuart, Joshua; K. Wong, Christopher; Yau, Christina; Neil Hayes, D.; S. Parker, Joel; D. Wilkerson, Matthew; Ally, Adrian; Balasundaram, Miruna; Bowlby, Reanne; Brooks, Denise; Carlsen, Rebecca; Chuah, Eric; Dhalla, Noreen; A. Holt, Robert; J.M. Jones, Steven; Kasaian, Katayoon; Lee, Darlene; Ma, Yussanne; A. Marra, Marco; Mayo, Michael; A. Moore, Richard; J. Mungall, Andrew; Mungall, Karen; Gordon Robertson, A.; Sadeghi, Sara; E. Schein, Jacqueline; Sipahimalani, Payal; Tam, Angela; Thiessen, Nina; Tse, Kane; Wong, Tina; C. Berger, Ashton; Beroukhim, Rameen; D. Cherniack, Andrew; Cibulskis, Carrie; Gabriel, Stacey; F. Gao, Galen; Ha, Gavin; Meyerson, Matthew; E. Schumacher, Steven; Shih, Juliann; H. Kucherlapati, Melanie; Kucherlapati, Raju; B. Baylin, Stephen; Cope, Leslie; Danilova, Ludmila; S. Bootwalla, Moiz; H. Lai, Phillip; T. Maglinte, Dennis; Van Den Berg, David; J. Weisenberger, Daniel; Todd Auman, J.; Balu, Saianand; Bodenheimer, Tom; Fan, Cheng; A. Hoadley, Katherine; P. Hoyle, Alan; R. Jefferys, Stuart; D. Jones, Corbin; Meng, Shaowu; A. Mieczkowski, Piotr; E. Mose, Lisle; H. Perou, Amy; M. Perou, Charles; Roach, Jeffrey; Shi, Yan; V. Simons, Janae; Skelly, Tara; G. Soloway, Matthew; Tan, Donghui; Veluvolu, Umadevi; Fan, Huihui; Hinoue, Toshinori; W. Laird, Peter; Shen, Hui; Zhou, Wanding; Bellair, Michelle; Chang, Kyle; R. Covington, Kyle; J. Creighton, Chad; Dinh, Huyen; Doddapaneni, HarshaVardhan; A. Donehower, Lawrence; Drummond, Jennifer; A. Gibbs, Richard; Glenn, Robert; Hale, Walker; Han, Yi; Hu, Hai; Korchina, Viktoriya; Lee, Sandra; Lewis, Lora; Li, Wei; Liu, Xiuping; Morgan, Margaret; Morton, Donna; M. Muzny, Donna; Santibanez, Jireh; Sheth, Margi; Shinbrot, Eve; Wang, Linghua; Wang, Min; A. Wheeler, David; Liu, Xi; Zhao, Fengmei; M. Hess, Julian; L. Appelbaum, Elizabeth; H. Bailey, Matthew; G. Cordes, Matthew; Li, Ding; C. Fronick, Catrina; A. Fulton, Lucinda; S. Fulton, Robert; Kandoth, Cyriac; R. Mardis, Elaine; D. McLellan, Michael; A. Miller, Christopher; K. Schmidt, Heather; K. Wilson, Richard; Crain, Daniel; Curley, Erin; Gardner, Johanna; Lau, Kevin; Mallery, David; Morris, Scott; Paulauskis, Joseph; Penny, Robert; Shelton, Candace; Shelton, Troy; E. Sherman, Mark; M. Thompson, Eric; Yena, Peggy; Bowen, Jay; M. Gastier-Foster, Julie; Gerken, Mark; M. Leraas, Kristen; M. Lichtenberg, Tara; C. Ramirez, Nilsa; Wise, Lisa; Zmuda, Erik; M. Corcoran, Niall; Costello, Tony; M. Hovens, Christopher; Lopes Carvalho, André; Carolina de Carvalho, Ana; Humberto Tavares Guerreiro Fregnani, José; Longatto‐Filho, Adhemar; Manuel Reis, Rui; Scapulatempo‐Neto, Cristovam; C.S. Silveira, Henrique; Onofre Vidal, Daniel; Burnette, Andrew; Eschbacher, Jennifer; Hermes, Beth; Noss, Ardene; Singh, Rosy; L. Anderson, Matthew; D. Castro, Patricia; Ittmann, Michael; Huntsman, David; Kohl, Bernard; Le, Xuan; Thorp, Richard; Andry, Chris; R. Duffy, Elizabeth; Lyadov, Vladimir; Paklina, Oxana; Setdikova, Galiya; Av, Shabunin; Tavobilov, Mikhail; McPherson, Christopher; E. Warnick, Ronald; S. Berkowitz, Ross; W. Cramer, Daniel; M. Feltmate, Colleen; S. Horowitz, Neil; S. Kibel, Adam; G. Muto, Michael; P. Raut, Chandrajit; Malykh, Andrei; S. Barnholtz‐Sloan, Jill; Barrett, Wendi; Devine, Karen; Fulop, Jordonna; T. Ostrom, Quinn; Shimmel, Kristen; Wolinsky, Yingli; E. Sloan, Andrew; Maria De Rose, Agostino; Giuliante, Felice; T. Goodman, Marc; Y. Karlan, Beth; H. Hagedorn, Curt; Eckman, John; Harr, Jodi; Myers, Jerome; Tucker, Kelinda; Anne Zach, Leigh; Deyarmin, Brenda; Hu, Hai; Kvecher, Leonid; Larson, Caroline; Mural, Richard; Somiari, Stella; Vícha, Aleš; Zelinka, Tomáš; Bennett, Joseph; Iacocca, Mary; Rabeno, Brenda; Swanson, Patricia; Latour, Mathieu; Lacombe, Louis; Têtu, Bernard; Bergeron, Alain; McGraw, Mary; M. Staugaitis, Susan; A. Chabot, John; Hibshoosh, Hanina; R. Sepulveda, Antonia; Su, Tao; C. Wang, Timothy; Potapova, Olga; L. Voronina, Olga; Desjardins, Laurence; Mariani, Odette; Roman‐Roman, Sergio; Sastre, Xavier; Stern, Marc‐Henri; Cheng, Feixiong; Signoretti, Sabina; Berchuck, Andrew; D. Bigner, Darell; Lipp, Eric; S. Marks, Jeffrey; J. McCall, Shannon; E. McLendon, Roger; Alvarez Secord, Angeles; Sharp, Alexis; Behera, Madhusmita; J. Brat, Daniel; Chen, Amy; A. Delman, Keith; Force, Seth; R. Khuri, Fadlo; R. Magliocca, Kelly; K. Maithel, Shishir; J. Olson, Jeffrey; K. Owonikoko, Taofeek; Pickens, Alan; S. Ramalingam, Suresh; M. Shin, Dong; Sica, Gabriel; G. Van Meir, Erwin; Zhang, Hongzheng; Eijckenboom, Wil; Gillis, Ad; Korpershoek, Esther; H. J. Looijenga, Leendert; Oosterhuis, Wolter; Stoop, Hans; E. van Kessel, Kim; C. Zwarthoff, Ellen; Calatozzolo, Chiara; Cuppini, Lucia; Cuzzubbo, Stefania; DiMeco, Francesco; Finocchiaro, Gaetano; Mattei, Luca; Perin, Alessandro; Pollo, Bianca; Chen, Chu; C. Houck, J.; Lohavanichbutr, Pawadee; Hartmann, Arndt; Stoehr, Robert; Stoehr, Robert; Täubert, Helge; Wach, Sven; Wullich, Bernd; Kycler, Witold; Murawa, Dawid; Wiznerowicz, Maciej; Wung Chung, Ki; Jeffrey Edenfield, W.; Martin, Julie; Baudin, Éric; J. Bubley, Glenn; Bueno, Raphael; De Rienzo, Assunta; G. Richards, William; N. Kalkanis, Steven; Mikkelsen, Tom; Noushmehr, Houtan; Scarpace, Lisa; Girard, Nicolas; Aymerich, Marta; Campo, Elı́as; Giné, Eva; López Guillermo, Armando; Van Bang, Nguyen; Thi Hanh, Phan; Đức Phú, Bùi; Tang, Yufang; Colman, Howard; Evason, Kimberley; R. Dottino, Peter; A. Martignetti, John; Gabra, Hani; Juhl, Hartmut; Akeredolu, Teniola; Stepa, Serghei; S.�B. Hoon, Dave; Ahn, Keunsoo; Jeong Kang, Koo; Beuschlein, Felix; Breggia, Anne; J. Birrer, Michael; Bell, Debra; J. Borad, Mitesh; H. Bryce, Alan; P. Castle, Erik; S. Chandan, Vishal; C. Cheville, John; A. Copland, John; B. Farnell, Michael; J. Flotte, Thomas; H. Giama, Nasra; H. Ho, Thai; L. Kendrick, Michael; Kocher, Jean‐Pierre; Kopp, Karla; D. Moser, Catherine; M. Nagorney, David; J. O’Brien, Daniel; Patrick O’Neill, Brian; Patel, Tushar; M. Petersen, Gloria; G. Que, Florencia; Rivera, Michael; R. Roberts, Lewis; C. Smallridge, Robert; C. Smyrk, Thomas; Stanton, Melissa; Houston Thompson, R.; Torbenson, Michael; Yang, Ju; Zhang, Lizhi; Brimo, Fadi; A. Ajani, Jaffer; Maria Angulo Gonzalez, Ana; Behrens, Carmen; Bondaruk, Jolanta; R. Broaddus, Russell; Czerniak, Bogdan; Esmaeli, Bita; Fujimoto, Junya; Gershenwald, Jeffrey; C. Guo, Charles; J. Lazar, Alexander; J. 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doi:10.1016/j.ccell.2018.03.014

Public

A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers

Published in Cancer Cell • Apr 1, 2018

Authors:

Ashton C. Berger

Anil Korkut

Rupa S. Kanchi

Abstract

We analyzed molecular data on 2,579 tumors from The Cancer Genome Atlas (TCGA) of four gynecological types plus breast. Our aims were to identify shared and unique molecular features, clinically significant subtypes, and potential therapeutic targets. We found 61 somatic copy-number alterations (SCN...

Subject

Breast cancer

Biology

Somatic cell

Research Assistant

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