Modern Approaches for Asymmetric Construction of Carbon–Fluorine Quaternary Stereogenic Centers: Synthetic Challenges and Pharmaceutical Needs

Zhu, Yi; Han, Jianlin; Wang, Jiandong; Shibata, Norio; Sodeoka, Mikiko; A. Soloshonok, Vadim; A. S. Coelho, Jaime; Dean Toste, F.

doi:10.1021/acs.chemrev.7b00778

Public

Modern Approaches for Asymmetric Construction of Carbon–Fluorine Quaternary Stereogenic Centers: Synthetic Challenges and Pharmaceutical Needs

Published in Chemical Reviews • Apr 2, 2018

Authors:

Yi Zhu

Jianlin Han

Jiandong Wang

Abstract

New methods for preparation of tailor-made fluorine-containing compounds are in extremely high demand in nearly every sector of chemical industry. The asymmetric construction of quaternary C-F stereogenic centers is the most synthetically challenging and, consequently, the least developed area of re...

Subject

Stereocenter

Chemistry

Quaternary

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