SIRT3 restricts hepatitis B virus transcription and replication through epigenetic regulation of covalently closed circular DNA involving suppressor of variegation 3‐9 homolog 1 and SET domain containing 1A histone methyltransferases

Ren, Ji‐Hua; Hu, Jieli; Cheng, Sheng‐Tao; Yu, Haibo; Kam Wai Wong, Vincent; Yuen Kwan Law, Betty; Yang, Yongfeng; Huang, Ying; Liu, Yi; Chen, Weixian; Cai, Xue‐Fei; Tang, Hua; Hu, Yuan; Zhang, Wenlu; Liu, Xiang; Long, Quanxin; Zhou, Li; Tao, Na‐Na; Zhou, Hong‐Zhong; Yang, Qiu‐Xia; Ren, Fang; He, Lin; Gong, Rui; Huang, Ailong; Chen, Juan

doi:10.1002/hep.29912

Public

SIRT3 restricts hepatitis B virus transcription and replication through epigenetic regulation of covalently closed circular DNA involving suppressor of variegation 3‐9 homolog 1 and SET domain containing 1A histone methyltransferases

Published in Hepatology • Apr 6, 2018

Authors:

Ji‐Hua Ren

Jieli Hu

Sheng‐Tao Cheng

Abstract

Hepatitis B virus (HBV) infection remains a major health problem worldwide. Maintenance of the covalently closed circular DNA (cccDNA), which serves as a template for HBV RNA transcription, is responsible for the failure of eradicating chronic HBV during current antiviral therapy. cccDNA is assemble...

Subject

cccDNA

Biology

Chromatin

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