Chronic Lymphocytic Leukemia B-Cell Normal Cellular Counterpart: Clues From a Functional Perspective

Darwiche, Walaa; Gubler, Brigitte; Marolleau, Jean‐Pierre; Ghamlouch, Hussein

doi:10.3389/fimmu.2018.00683

Public

Chronic Lymphocytic Leukemia B-Cell Normal Cellular Counterpart: Clues From a Functional Perspective

Published in Frontiers in Immunology • Apr 4, 2018

Authors:

Walaa Darwiche

Brigitte Gubler

Jean‐Pierre Marolleau

Abstract

Chronic lymphocytic leukemia (CLL) is characterized by the clonal expansion of small mature-looking CD19+ CD23+ CD5+ B-cells that accumulate in the blood, bone marrow, and lymphoid organs. To date, no consensus has been reached concerning the normal cellular counterpart of CLL B-cells and several B-...

Subject

Chronic lymphocytic leukemia

Biology

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