Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

A. Hoadley, Katherine; Yau, Christina; Hinoue, Toshinori; M. Wolf, Denise; J. Lazar, Alexander; Drill, Esther; Shen, Ronglai; M. Taylor, Alison; D. Cherniack, Andrew; Thórsson, Vésteinn; Akbani, Rehan; Bowlby, Reanne; K. Wong, Christopher; Wiznerowicz, Maciej; Sánchez-Vega, Francisco; R. Roberts, Lewis; Schneider, Barbara; S. Lawrence, Michael; Noushmehr, Houtan; M. Malta, Tathiane; Johnson, Rory; A. Demchok, John; Felau, Ina; Kasapi, Melpomeni; L. Ferguson, Martin; M. Hutter, Carolyn; J. Sofia, Heidi; Tarnuzzer, Roy; Wang, Zhining; Yang, Liming; C. Zenklusen, Jean; Zhang, Jiashan; Chudamani, Sudha; Liu, Jia; Lolla, Laxmi; Naresh, Rashi; Pihl, Todd; Sun, Qiang; Wan, Yunhu; Wu, Ye; Cho, Juok; Defreitas, Timothy; Frazer, Scott; Gehlenborg, Nils; Getz, Gad; I. Heiman, David; Kim, Jaegil; S. Lawrence, Michael; Lin, Pei; Meier, Sam; S. Noble, Michael; Saksena, Gordon; Voet, Doug; Zhang, Hailei; Bernard, Brady; Chambwe, Nyasha; Dhankani, Varsha; Knijnenburg, Theo; Kramer, Roger; Leinonen, Kalle; Liu, Yuexin; Miller, Michael; M. Reynolds, Sheila; Shmulevich, Ilya; Thórsson, Vésteinn; Zhang, Wei; Akbani, Rehan; M. Broom, Bradley; M. Hegde, Apurva; Ju, Zhenlin; S. Kanchi, Rupa; Korkut, Anil; Li, Jun; Liang, Han; Ling, Shiyun; Liu, Wenbin; Lu, Yiling; B. Mills, Gordon; Ng, Kwok-Shing; Rao, Arvind; P. Ryan, Michael; Wang, Jing; N. Weinstein, John; Zhang, Jiexin; Abeshouse, Adam; Armenia, Joshua; Chakravarty, Debyani; K. Chatila, Walid; de Bruijn, Ino; F. Gao, Galen; Groß, Benjamin; Heins, Zachary; Kundra, Ritika; La, Konnor; Ladanyi, Marc; Luna, Augustin; G. Nissan, Moriah; Ochoa, Angelica; Phillips, Sarah; Reznik, Ed; Sánchez-Vega, Francisco; Sander, Chris; Schultz, Nikolaus; P. Sheridan, Robert; Onur Sumer, S.; Sun, Yichao; S. Taylor, Barry; Wang, Jioajiao; Zhang, Hongxin; Anur, Pavana; Peto, Myron; T. Spellman, Paul; C. Benz, Christopher; M. Stuart, Joshua; K. Wong, Christopher; Yau, Christina; Neil Hayes, D.; S. Parker, Joel; D. Wilkerson, Matthew; Ally, Adrian; Balasundaram, Miruna; Bowlby, Reanne; Brooks, Denise; Carlsen, Rebecca; Chuah, Eric; Dhalla, Noreen; A. Holt, Robert; J.M. Jones, Steven; Kasaian, Katayoon; Lee, Darlene; Ma, Yussanne; A. Marra, Marco; Mayo, Michael; A. Moore, Richard; J. Mungall, Andrew; Mungall, Karen; R. Roberts, Lewis; Sadeghi, Sara; E. Schein, Jacqueline; Sipahimalani, Payal; Tam, Angela; Thiessen, Nina; Tse, Kane; Wong, Tina; C. Berger, Ashton; Beroukhim, Rameen; D. Cherniack, Andrew; Cibulskis, Carrie; Gabriel, Stacey; F. Gao, Galen; Ha, Gavin; Meyerson, Matthew; E. Schumacher, Steven; Shih, Juliann; H. Kucherlapati, Melanie; Kucherlapati, Raju; B. Baylin, Stephen; Cope, Leslie; Danilova, Ludmila; S. Bootwalla, Moiz; H. Lai, Phillip; T. Maglinte, Dennis; Van Den Berg, David; J. Weisenberger, Daniel; Todd Auman, J.; Balu, Saianand; Bodenheimer, Tom; Fan, Cheng; A. Hoadley, Katherine; P. Hoyle, Alan; R. Jefferys, Stuart; D. Jones, Corbin; Meng, Shaowu; A. Mieczkowski, Piotr; E. Mose, Lisle; H. Perou, Amy; M. Perou, Charles; Roach, Jeffrey; Shi, Yan; V. Simons, Janae; Skelly, Tara; G. Soloway, Matthew; Tan, Donghui; Veluvolu, Umadevi; Fan, Huihui; Hinoue, Toshinori; W. Laird, Peter; Shen, Hui; Zhou, Wanding; Bellair, Michelle; Chang, Kyle; R. Covington, Kyle; J. Creighton, Chad; Dinh, Huyen; Doddapaneni, HarshaVardhan; A. Donehower, Lawrence; Drummond, Jennifer; A. Gibbs, Richard; Glenn, Robert; Hale, Walker; Han, Yi; Hu, Hai; Korchina, Viktoriya; Lee, Sandra; Lewis, Lora; Li, Wei; Liu, Xiuping; Morgan, Margaret; Morton, Donna; M. Muzny, Donna; Santibanez, Jireh; Sheth, Margi; Shinbrot, Eve; Wang, Linghua; Wang, Min; A. Wheeler, David; Liu, Xi; Zhao, Fengmei; M. Hess, Julian; L. Appelbaum, Elizabeth; H. Bailey, Matthew; G. Cordes, Matthew; Ding, Li; C. Fronick, Catrina; A. Fulton, Lucinda; S. Fulton, Robert; Kandoth, Cyriac; R. Mardis, Elaine; D. McLellan, Michael; A. Miller, Christopher; K. Schmidt, Heather; K. Wilson, Richard; Crain, Daniel; Curley, Erin; Gardner, Johanna; Lau, Kevin; Mallery, David; Morris, Scott; Paulauskis, Joseph; Penny, Robert; Shelton, Candace; Shelton, Troy; E. Sherman, Mark; M. Thompson, Eric; Yena, Peggy; Bowen, Jay; M. Gastier-Foster, Julie; Gerken, Mark; Leraas, Kristen; M. Lichtenberg, Tara; C. Ramirez, Nilsa; Wise, Lisa; Zmuda, Erik; M. Corcoran, Niall; Costello, Tony; M. Hovens, Christopher; Lopes Carvalho, André; Carolina de Carvalho, Ana; Humberto Tavares Guerreiro Fregnani, José; Longatto‐Filho, Adhemar; Manuel Reis, Rui; Scapulatempo‐Neto, Cristovam; C.S. Silveira, Henrique; Onofre Vidal, Daniel; Burnette, Andrew; Eschbacher, Jennifer; Hermes, Beth; Noss, Ardene; Singh, Rosy; L. Anderson, Matthew; D. Castro, Patricia; Ittmann, Michael; G. Huntsman, David; Kohl, Bernard; Le, Xuan; Thorp, Richard; Andry, Chris; R. Duffy, Elizabeth; Lyadov, Vladimir; Paklina, Oxana; Setdikova, Galiya; Av, Shabunin; Tavobilov, Mikhail; McPherson, Christopher; E. Warnick, Ronald; S. Berkowitz, Ross; Cramer, Daniel; M. Feltmate, Colleen; S. Horowitz, Neil; S. Kibel, Adam; G. Muto, Michael; P. Raut, Chandrajit; Malykh, Andrei; S. Barnholtz‐Sloan, Jill; Barrett, Wendi; Devine, Karen; Fulop, Jordonna; T. Ostrom, Quinn; Shimmel, Kristen; Wolinsky, Yingli; E. Sloan, Andrew; Maria De Rose, Agostino; Giuliante, Felice; T. Goodman, Marc; Y. Karlan, Beth; H. Hagedorn, Curt; Eckman, John; Harr, Jodi; K. Myers, Jerome; Tucker, Kelinda; Anne Zach, Leigh; Deyarmin, Brenda; Hu, Hai; Kvecher, Leonid; Larson, Caroline; Mural, Richard; Somiari, Stella; Vícha, Aleš; Zelinka, Tomáš; Bennett, Joseph; Iacocca, Mary; Rabeno, Brenda; Swanson, Patricia; Latour, Mathieu; Lacombe, Louis; Têtu, Bernard; Bergeron, Alain; McGraw, Mary; M. Staugaitis, Susan; A. Chabot, John; Hibshoosh, Hanina; R. Sepulveda, Antonia; Su, Tao; C. Wang, Timothy; Potapova, Olga; Voronina, Olga; Desjardins, Laurence; Mariani, Odette; Roman‐Roman, Sergio; Sastre, Xavier; Stern, Marc‐Henri; Cheng, Feixiong; Signoretti, Sabina; Berchuck, Andrew; D. Bigner, Darell; Lipp, Eric; S. Marks, Jeffrey; J. McCall, Shannon; E. McLendon, Roger; Alvarez Secord, Angeles; Sharp, Alexis; Behera, Madhusmita; J. Brat, Daniel; Chen, Amy; A. Delman, Keith; Force, Seth; R. Khuri, Fadlo; R. Magliocca, Kelly; K. Maithel, Shishir; J. Olson, Jeffrey; K. Owonikoko, Taofeek; Pickens, Alan; S. Ramalingam, Suresh; Min Shin, Dong; Sica, Gabriel; G. Van Meir, Erwin; Zhang, Hongzheng; Eijckenboom, Wil; Gillis, Ad; Korpershoek, Esther; H. J. Looijenga, Leendert; Oosterhuis, Wolter; Stoop, Hans; E. van Kessel, Kim; C. Zwarthoff, Ellen; Calatozzolo, Chiara; Cuppini, Lucia; Cuzzubbo, Stefania; DiMeco, Francesco; Finocchiaro, Gaetano; Mattei, Luca; Perin, Alessandro; Pollo, Bianca; Chu, Chen; C. Houck, J.; Lohavanichbutr, Pawadee; Hartmann, Arndt; Stoehr, Robert; Stoehr, Robert; Täubert, Helge; Wach, Sven; Wullich, Bernd; Kycler, Witold; Murawa, Dawid; Wiznerowicz, Maciej; Wung Chung, Ki; Jeffrey Edenfield, W.; Martin, Julie; Baudin, Éric; J. Bubley, Glenn; Bueno, Raphael; De Rienzo, Assunta; G. Richards, William; N. Kalkanis, Steven; Mikkelsen, Tom; Noushmehr, Houtan; Scarpace, Lisa; Girard, Nicolas; Aymerich, Marta; Campo, Elı́as; Giné, Eva; López Guillermo, Armando; Van Bang, Nguyen; Thi Hanh, Phan; Đức Phú, Bùi; Tang, Yufang; Colman, Howard; Evason, Kimberley; R. Dottino, Peter; A. Martignetti, John; Gabra, Hani; Juhl, Hartmut; Akeredolu, Teniola; Stepa, Serghei; S.�B. Hoon, Dave; Ahn, Keunsoo; Jeong Kang, Koo; Beuschlein, Felix; Breggia, Anne; J. Birrer, Michael; Bell, Debra; J. Borad, Mitesh; H. Bryce, Alan; P. Castle, Erik; S. Chandan, Vishal; C. Cheville, John; A. Copland, John; B. Farnell, Michael; J. Flotte, Thomas; H. Giama, Nasra; H. Ho, Thai; L. Kendrick, Michael; Kocher, Jean‐Pierre; Kopp, Karla; D. Moser, Catherine; M. Nagorney, David; R. O’Brien, Daniel; Patrick O’Neill, Brian; Patel, Tushar; Petersen, Gloria; G. Que, Florencia; Rivera, Michael; R. Roberts, Lewis; C. Smallridge, Robert; C. Smyrk, Thomas; Stanton, Melissa; Houston Thompson, R.; Torbenson, Michael; Dong Yang, Ju; Zhang, Lizhi; Brimo, Fadi; A. Ajani, Jaffer; Maria Angulo Gonzalez, Ana; Behrens, Carmen; Bondaruk, olanta; R. Broaddus, Russell; Czerniak, Bogdan; Esmaeli, Bita; Fujimoto, Junya; Gershenwald, Jeffrey; C. Guo, Charles; J. Lazar, Alexander; J. Logothetis, Christopher; Meric‐Bernstam, Funda; A. Moran, César; M. Ramondetta, Lois; Rice, David; K. Sood, Anil; Tamboli, Pheroze; Thompson, Timothy; Troncoso, Patricia; S. Tsao, Anne; Wistuba, Ignacio; Carter, Candace; E. Haydu, Lauren; Hersey, Peter; Jakrot, Valerie; Kakavand, Hojabr; Kefford, Richard; Lee, Kenneth; V. Long, Georgina; J. Mann, Graham; Quinn, Michael; P.M. Saw, Robyn; A. Scolyer, Richard; F. Shannon, Kerwin; J. Spillane, Andrew; R. Stretch, Jonathan; Synott, Maria; F. Thompson, John; S. Wilmott, James; Al‐Ahmadie, Hikmat; A. Chan, Timothy; Ghossein, Ronald; Gopalan, Anuradha; A. Levine, Douglas; Reuter, Victor; Singer, Samuel; Singh, Bhuvanesh; Viet Tien, Nguyen; Broudy, Thomas; Mirsaidi, Cyrus; Nair, Praveen; Drwiega, Paul; Miller, Judy; R. Smith, Jennifer; A. Zaren, Howard; Park, Joong‐Won; Phi Hùng, Nguyễn; Kebebew, Electron; Marston Linehan, W.; R. Metwalli, Adam; Pacák, Karel; A. Pinto, Peter; Schiffman, Mark; S. Schmidt, Laura; D. Vocke, Cathy; Wentzensen, Nicolas; Worrell, Robert; Yang, Hannah; Moncrieff, Marc; Goparaju, Chandra; Melamed, Jonathan; I. Pass, Harvey; Botnariuc, Natalia; Caraman, Irina; Cernat, Mircea; Chemencedji, Inga; Clipca, Adrian; Doruc, Serghei; Gorincioi, Ghenadie; Mura, Sergiu; Pirtac, Maria; Stancul, Irina; Tcaciuc, Diana; Albert, Monique; Alexopoulou, Iakovina; Arnaout, Angel; G. Bartlett, John; Engel, Jay; Gilbert, Sébastien; Parfitt, Jeremy; Sekhon, Harman; Thomas, George; M. Rassl, Doris; C. Rintoul, Robert; Bifulco, Carlo; Tamakawa, Raina; J. Urba, Walter; K. Hayward, Nicholas; Timmers, Henri; Antenucci, Anna; Facciolo, Francesco; Luca Grazi, Gian; Marino, Mirella; Merola, Roberta; R. de Krijger, Ronald; Gimenez‐Roqueplo, Anne‐Paule; Piché, Alain; Chevalier, Simone; McKercher, Ginette; Birsoy, Kıvanç; H. Barnett, Gene; Brewer, Cathy; Farver, Carol; Naska, Theresa; A. Pennell, Nathan; Raymond, Daniel; Schilero, Cathy; Smolenski, Kathy; Williams, Felicia; Morris, Quaid; A. Borgia, Jeffrey; J. Liptay, Michael; Pool, Mark; W. Seder, Christopher; Junker, Kerstin; Omberg, Larsson; Dinkin, Mikhail; Manikhas, George; Alvaro, Domenico; Consiglia Bragazzi, Maria; Cardinale, Vincenzo; Carpino, Guido; Gaudio, Eugenio; Chesla, David; Cottingham, Sandra; Dubina, Michael; Moiseenko, Fedor; Dhanasekaran, Renumathy; Becker, Karl‐Friedrich; Janssen, Klaus‐Peter; Slotta‐Huspenina, Julia; H. Abdel‐Rahman, Mohamed; Aziz, Dina; Bell, Sue; M. Cebulla, Colleen; Davis, Amy; Duell, Rebecca; Bradley Elder, J.; Hilty, Joe; Kumar, Bahavna; C. Lang, James; L. Lehman, Norman; Mandt, Randy; Nguyen, Phuong; Pilarski, Robert; Rai, Karan; Schoenfield, Lynn; Senecal, Kelly; E. Wakely, Paul; Hansen, Paul; M. Lechan, Ronald; Powers, James; S. Tischler, Arthur; E. Grizzle, William; C. Sexton, Katherine; Kastl, Alison; Henderson, Joel; P. Porten, Sima; Waldmann, Jens; Faßnacht, Martin; Sylvia, L.; Schadendorf, Dirk; Couce, Marta; Graefen, Markus; Huland, Hartwig; Sauter, Guido; Schlomm, Thorsten; Simon, Ronald; Tennstedt, Pierre; Olabode, Oluwole; A. Nelson, Mark; F. Bathe, Oliver; R. Carroll, Peter; M. Chan, June; J. DiSaia, Philip; Glenn, Pat; Kate Kelley, Robin; N. Landen, Charles; Phillips, Joanna; D. Prados, Michael; Simko, Jeffry; Smith‐McCune, Karen; R. VandenBerg, Scott; K. Roggin, Kevin; Fehrenbach, Ashley; Kendler, Ady; Sifri, Suzanne; Steele, Ruth; Jimeno, Antonio; A. Carey, Francis; Forgie, Ian; Mannelli, Massimo; E. Carney, Michael; Hernandez, Brenda; Campos, Benito; Herold‐Mende, Christel; Jungk, Christin; Unterberg, Andreas; von Deimling, Andreas; Bossler, Aaron; Galbraith, Joseph; Jacobus, Laura; Knudson, Michael; Knutson, Tina; Ma, Deqin; Milhem, Mohammed; Sigmund, Rita; K. Godwin, Andrew; Madan, Rashna; G. Rosenthal, Howard; Adebamowo, Clement; N. Adebamowo, Sally; Boussioutas, Alex; G. Beer, David; J. Giordano, Thomas; Mes‐Masson, Anne‐Marie; Saad, Fred; Bocklage, Thèrése; M. Landrum, Lisa; S. Mannel, Robert; N. Moore, Kathleen; Moxley, Katherine; Postier, Russel; Walker, Joan; E. Zuna, Rosemary; D. Feldman, Michael; Valdivieso, Federico; Dhir, Rajiv; D. Luketich, James; M. Mora Pinero, Edna; Quintero-Aguilo, Mario; Gilberto Carlotti, Carlos; Sebastião dos Santos, José; Kemp, Rafael; Sankarankuty, Ajith; Pretti da Cunha Tirapelli, Daniela; W.F. Catto, James; Agnew, Kathy; M. Swisher, Elizabeth; Creaney, Jenette; Robinson, Bruce; Simon Shelley, Carl; M. Godwin, Eryn; Kendall, Sara; Shipman, Cassaundra; R. Bradford, Carol; E. Carey, Thomas; Haddad, Andrea; Moyer, Jeffey; A. Peterson, Lisa; E. Prince, Mark; S. Rozek, Laura; T. Wolf, Gregory; Bowman, Rayleen; M. Fong, Kwun; A. Yang, Ian; J. Korst, Robert; Kimryn Rathmell, W.; Leigh Fantacone-Campbell, J.; A. Hooke, Jeffrey; J. Kovatich, Albert; D. Shriver, Craig; F. DiPersio, John; F. Drake, Bettina; Govindan, Ramaswamy; E. Heath, Sharon; J. Ley, Timothy; A. Van Tine, Brian; Westervelt, Peter; A. Rubin, Mark; Il Lee, Jung; D. Aredes, Natália; Mariamidze, Armaz; M. Stuart, Joshua; C. Benz, Christopher; W. Laird, Peter

doi:10.1016/j.cell.2018.03.022

Public

Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

Published in Cell • Apr 1, 2018

Authors:

Katherine A. Hoadley

Christina Yau

Toshinori Hinoue

Abstract

We conducted comprehensive integrative molecular analyses of the complete set of tumors in The Cancer Genome Atlas (TCGA), consisting of approximately 10,000 specimens and representing 33 types of cancer. We performed molecular clustering using data on chromosome-arm-level aneuploidy, DNA hypermethy...

Subject

Biology

DNA methylation

Cancer

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!