The Immune Landscape of Cancer

Thórsson, Vésteinn; Thorsson, Vésteinn; L. Gibbs, David; Brown, Scott; Wolf, Denise; S. Bortone, Dante; Ou Yang, Tai-Hsien; Porta-Pardo, Eduard; F. Gao, Galen; L. Plaisier, Christopher; A. Eddy, James; Ziv, Elad; C. Culhane, Aedín; Paull, Evan; Ashok Sivakumar, I.K.; J. Gentles, Andrew; Malhotra, Raunaq; Farshidfar, Farshad; Colaprico, Antonio; S. Parker, Joel; E. Mose, Lisle; Sy Vo, Nam; Liu, Yuexin; Liu, Y; Rader, Janet; Dhankani, Varsha; M. Reynolds, Sheila; Bowlby, Reanne; Califano, Andrea; D. Cherniack, Andrew; Anastassiou, Dimitris; Bedognetti, Davide; Mokrab, Younes; M. Newman, Aaron; Rao, Arvind; Chen, Ken; Krasnitz, Alexander; Hu, Hai; M. Malta, Tathiane; Noushmehr, Houtan; Sekhar Pedamallu, Chandra; Bullman, Susan; I. Ojesina, Akinyemi; Lamb, Andrew; Zhou, Wanding; Shen, Hui; K. Choueiri, Toni; N. Weinstein, John; Guinney, Justin; Saltz, Joel; A. Holt, Robert; S. Rabkin, Charles; Johnson, Rory; A. Demchok, John; Felau, Ina; Kasapi, Melpomeni; L. Ferguson, Martin; M. Hutter, Carolyn; J. Sofia, Heidi; Tarnuzzer, Roy; Yang, Liming; Yang, Liming; C. Zenklusen, Jean; Zhang, Jiashan; Chudamani, Sudha; Liu, Jia; Lolla, Laxmi; Naresh, Rashi; Pihl, T; Sun, Qiang; Wu, Ye; Wu, Ye; Cho, Juok; Defreitas, Timothy; Frazer, Scott; Gehlenborg, Nils; Gs, Getz; I. Heiman, David; Kim, Jaegil; S. Lawrence, Michael; Lin, Pei; Meier, Sam; S. Noble, Michael; Saksena, Gordon; Voet, Doug; Zhang, Hailei; Bernard, Brady; Chambwe, Nyasha; Dhankani, Varsha; Knijnenburg, Theo; Kramer, Roger; Leinonen, Kalle; Liu, Yuexin; Miller, Michael; Reynolds, Sheila; Shmulevich, Ilya; Thorsson, Vésteinn; Thorsson, Vesteinn; Zhang, Wei; Akbani, Rehan; M. Broom, Bradley; M. Hegde, Apurva; Ju, Zhenlin; S. Kanchi, Rupa; K Korkut, A; Ling, Shiyun; Liang, Han; Ling, Shiyun; Liu, Wenbin; Lu, Yiling; B. Mills, Gordon; Ng, Kwok-Shing; Rao, Arvind; Ryan, Michael; Zhang, Jiexin; N. Weinstein, John; Zhang, Jiexin; Abeshouse, Adam; Armenia, Joshua; Chakravarty, Debyani; K. Chatila, Walid; de Bruijn, Ino; Gao, Jianjiong; E. Gross, Benjamin; Heins, Zachary; Kundra, Ritika; La, Konnor; Ladanyi, Marc; Luna, Augustin; G. Nissan, Moriah; Ochoa, Angelica; Phillips, Sarah; Reznik, Ed; Sanchez-Vega, Francisco; Sander, Chris; Schultz, Nikolaus; Sheridan, Robert; Onur Sumer, S.; Sun, Yichao; S. Taylor, Barry; Wang, Jioajiao; Zhang, Hongxin; Anur, Pavana; Peto, Myron; Spellman, P.; K. Wong, Christopher; M. Stuart, Joshua; K. Wong, Christopher; Yau, C; Neil Hayes, D.; S. Parker, Joel; D. Wilkerson, Matthew; Ai, Ally; Balasundaram, Miruna; Bowlby, Reanne; Brooks, Denise; Carlsen, Rebecca; Chuah, Eric; Dhalla, Noreen; Holt, Robert; J.M. Jones, Steven; Kasaian, Katayoon; Lee, Darlene; Mayo, Michael; A. Marra, Marco; Mayo, Michael; A. Moore, Richard; J. Mungall, Andrew; Mungall, Karen; Gordon Robertson, A.; Sadeghi, Sara; E. Schein, Jacqueline; Sipahimalani, Payal; Tam, Angela; Thiessen, Nina; Tse, Kane; Wong, Tina; C. Berger, Ashton; R, Beroukhim; D. Cherniack, Andrew; Cibulskis, Carrie; B. Gabriel, Stacey; F. Gao, Galen; Ha, Gavin; Meyerson, M.; E. Schumacher, Steven; Shih, Juliann; H. Kucherlapati, Melanie; Kucherlapati, Raju; SB, Baylin; Cope, Leslie; Danilova, Ludmila; Bootwalla, Moiz; H. Lai, Phillip; T. Maglinte, Dennis; J. Van Den Berg, David; J. Weisenberger, Daniel; Todd Auman, J.; Balu, Saianand; Bodenheimer, Tom; Fan, Cheng; A. Hoadley, Katherine; P. Hoyle, Alan; R. Jefferys, Stuart; D. Jones, Corbin; , 孟绍武; A. Mieczkowski, Piotr; E. Mose, Lisle; H. Perou, Amy; M. Perou, Charles; Roach, Jeffrey; Shi, Yan; V. Simons, Janae; Skelly, Tara; G. Soloway, Matthew; Fan, Huihui; Veluvolu, Umadevi; Fan, Huihui; Hinoue, Toshinori; W. Laird, Peter; Shen, Hui; Zhou, Wanding; Bellair, Michelle; Chang, Kyle; Covington, Kyle; J. Creighton, Chad; Dinh, Huyen; Doddapaneni, HarshaVardhan; Donehower, LA; Drummond, Jennifer; A. Gibbs, Richard; Glenn, Robert; Hale, Walker; Han, Yi; Hu, Jianhong; Korchina, Viktoriya; Lee, Sandra; Lewis, Lora; Li, Wei; Liu, Xiuping; Morgan, Margaret; Morton, Donna; Muzny, Donna; Santibanez, Jireh; Sheth, Margi; Shinbrot, Eve; Wang, Linghua; Wang, Min; A. Wheeler, David; Xi, Liu; Zhao, Fengmei; Hess, Julian; L. Appelbaum, Elizabeth; Bailey, Matthew; G. Cordes, Matthew; Ding, Li; C. Fronick, Catrina; A. Fulton, Lucinda; S. Fulton, Robert; Kandoth, Cyriac; Mardis, E; D. McLellan, Michael; A. Miller, Christopher; K. Schmidt, Heather; K. Wilson, Richard; Crain, Daniel; Curley, Erin; Gardner, Johanna; Lau, Kevin; Mallery, David; Morris, Scott; Paulauskis, Joseph; Penny, Robert; Shelton, Candace; Shelton, Troy; Sherman, Mark; Thompson, Eric; Yena, Peggy; Bowen, Jay; M. Gastier-Foster, Julie; Gerken, Mark; M. Leraas, Kristen; M. Lichtenberg, Tara; C. Ramirez, Nilsa; Wise, Lisa; Zmuda, Erik; Corcoran, Niall; Costello, Tony; Hovens, Christopher; L. Carvalho, André; C. de P. Carvalho, A.; H. Fregnani, José; Longatto‐Filho, Adhemar; M. Reis, Rui; Scapulatempo-Neto, Cristovam; C. S. Silveira, Henrique; O. Vidal, Daniel; Burnette, Andrew; Eschbacher, Jennifer; Hermes, Beth; Noss, Ardene; Singh, Rosy; L. Anderson, Matthew; D. Castro, Patricia; Ittmann, Michael; Huntsman, D; Kohl, Bernard; Le, Xuan; Thorp, Richard; Andry, Chris; R. Duffy, Elizabeth; Lyadov, Vladimir; Paklina, Oxana; R Setdikova, G; Shabunin, Alexey; Tavobilov, Mikhail; McPherson, Christopher; Warnick, Ronald; Berkowitz, Ross; Cramer, Daniel; Feltmate, Colleen; Nh, Horowitz; Kibel, Adam; Muto, Michael; P. Raut, Chandrajit; Malykh, Andrei; S. Barnholtz-Sloan, Jill; Barrett, Wendi; Devine, Karen; Fulop, Jordonna; T. Ostrom, Quinn; Shimmel, Kristen; Wolinsky, Yingli; E. Sloan, Andrew; De Rose, Agostino; Giuliante, Felice; Goodman, Marc; Y Karlan, B; H. Hagedorn, Curt; Eckman, John; R Harr, J; Myers, Jerome; Tucker, Kelinda; Anne Zach, Leigh; Deyarmin, Brenda; Hu, Hai; Kvecher, Leonid; Larson, Caroline; J. Mural, Richard; Somiari, Stella; Vícha, Aleš; Zelinka, Tomáš; Bennett, Joseph; Iacocca, Mary; Rabeno, Brenda; Swanson, Patricia; Latour, Mathieu; Lacombe, Louis; Têtu, Bernard; Bergeron, Alain; Mj, McGraw; M. Staugaitis, Susan; Chabot, John; Hibshoosh, Hanina; Sepúlveda, Antonia; Su, Tao; Wang, Timothy; Potapova, Olga; Voronina, Olga; Desjardins, Laurence; Mariani, Odette; Roman‐Roman, Sergio; Sastre, Xavier; Stern, Marc-Henri; Cheng, Feixiong; Signoretti, Sabina; Berchuck, Andrew; Bigner, Darell; Lipp, Eric; Marks, J; J. McCall, S.; McLendon, Roger; Secord, Angeles; Sharp, Alexis; R Behera, M; J. Brat, D.; Chen, Amy; Delman, Keith; Force, Seth; Khuri, Fadlo; Magliocca, K.; Maithel, Shishir; J. Olson, Jeffrey; Owonikoko, Taofeek; Pickens, Alan; Ramalingam, S; M. Shin, Dong; Sica, Gabriel; G. Van Meir, Erwin; Zhang, Hongzheng; Eijckenboom, Wil; Gillis, Ad; Korpershoek, Esther; Looijenga, Leendert; Oosterhuis, Wolter; Stoop, Hans; E. van Kessel, Kim; Ec, Zwarthoff; Calatozzolo, Chiara; Cuppini, Lucia; Cuzzubbo, Stefania; DiMeco, Francesco; Finocchiaro, Gaetano; Lf, Mattei; Perin, Alessandro; Pollo, Bianca; Chen, Chu; Houck, John; Lohavanichbutr, Pawadee; Hartmann, Arndt; Stoehr, Christine; S Stoehr, R; Taubert, Helge; Wach, Sven; Wullich, Bernd; Kycler, Witold; Murawa, D.; Wiznerowicz, Maciej; Chung, Ki; Edenfield, WJ; Martin, Julie; Baudin, Eric; Gj, Bubley; Bueno, Raphael; De Rienzo, Assunta; G. Richards, William; Kalkanis, Steven; Mikkelsen, Tom; Noushmehr, Houtan; Scarpace, L; Girard, Nicolas; Ml, Aymerich; Campo, Elias; Giné, Eva; López Guillermo, Armando; Van Bang, Nguyen; Thi Hanh, Phan; Duc Phu, Bui; Tang, Yufang; Colman, Howard; Evason, Kimberley; R. Dottino, Peter; A. Martignetti, John; Gabra, Hani; Juhl, Hartmut; Akeredolu, Teniola; Stepa, Serghei; Hoon, Dave; Ahn, Keunsoo; Jeong Kang, Koo; Beuschlein, Felix; Breggia, Anne; Birrer, Michael; Bell, Debra; Mj, Borad; H. Bryce, Alan; Castle, Erik; Chandan, Vishal; Cheville, John; Jw, Copland; Farnell, Michael; Flotte, Thomas; Giama, Nasra; Ho, Thai; Kendrick, Michael; Kocher, Jean-Pierre; Kopp, Karla; Moser, Catherine; David Nagorney, MD; O'Brien, Daniel; Patrick O’Neill, Brian; PATEL, TUSHAR; Petersen, Gloria; Que, Florencia; Rivera, Michael; Roberts, Lewis; Smallridge, Robert; Smyrk, Thomas; Stanton, Melissa; Houston Thompson, R.; Torbenson, Michael; Dong Yang, Ju; Zhang, Lizhi; Brimo, Fadi; A. Ajani, Jaffer; Maria Angulo Gonzalez, Ana; Behrens, Carmen; Bondaruk, Jolanta; Broaddus, Russell; Czerniak, Bogdan; Esmaeli, Bita; Fujimoto, Junya; Gershenwald, Jeffrey; Guo, Charles; J. Lazar, Alexander; Logothetis, C; Meric-Bernstam, Funda; Moran, Cesar; Ramondetta, Lois; Rice, D.; Sood, Anil; Tamboli, Pheroze; Thompson, Timothy; Troncoso, Patricia; Tsao, Anne; Wistuba, Ignacio; Carter, Candace; Haydu, Lauren; Hersey, P; Jakrot, Valerie; Kakavand, Hojabr; Kefford, Richard; Lee, Kenneth; Long, Georgina; Mann, Graham; Quinn, Michael; R, Saw; Scolyer, Richard; Shannon, Kerwin; Spillane, Andrew; Stretch, onathan; Synott, Maria; Thompson, John; Wilmott, James; Al-Ahmadie, Hikmat; A. Chan, Timothy; Ra, Ghossein; Gopalan, Anuradha; A. Levine, Douglas; Reuter, Victor; Singer, Samuel; Singh, Bhuvanesh; D Tien, N; Broudy, Thomas; Mirsaidi, Cyrus; Nair, Praveen; Drwiega, Paul; Miller, Judy; Smith, Jennifer; Zaren, Howard; Park, Joong-Won; Phi Hùng, Nguyễn; KEBEBEW, ELECTRON; Marston Linehan, W.; R. Metwalli, Adam; Pacak, Karel; A. Pinto, Peter; Schiffman, Mark; S. Schmidt, Laura; D. Vocke, Cathy; Wentzensen, N; Rv, Worrell; J. Yang, H.; Moncrieff, Marc; Goparaju, Chandra; Melamed, Jonathan; Pass, Harvey; Botnariuc, Natalia; Caraman, Irina; Cernat, Mircea; Chemencedji, Inga; Clipca, Adrian; Doruc, Serghei; Gorincioi, Ghenadie; Mura, Sergiu; Pirtac, Maria; Stancul, Irina; Tcaciuc, Diana; Albert, Monique; Alexopoulou, Iakovina; Arnaout, A; Bartlett, John; Engel, Jay; Gilbert, Sébastien; Parfitt, Jeremy; Sekhon, Harman; Thomas, George; M. Rassl, Doris; C. Rintoul, Robert; Bifulco, Carlo; Tamakawa, Raina; Urba, Walter; Hayward, Nicholas; Hw, Timmers; Antenucci, Anna; Facciolo, Francesco; Grazi, Gianluca; Marino, Mirella; Merola, Roberta; De Krijger, R.; Gimenez‐Roqueplo, Anne‐Paule; Piché, Alain; Chevalier, Simone; McKercher, Ginette; Birsoy, Kıvanç; Barnett, Gene; Brewer, Cathy; E. Farver, C.; Naska, Theresa; A. Pennell, Nathan; Raymond, Daniel; Schilero, Cathy; Smolenski, K; Williams, Felicia; Morrison, Carl; A. Borgia, Jeffrey; Liptay, M.; Pool, Mark; W Seder, C; Ks, Junker; Omberg, Larsson; Dinkin, Mikhail; Manikhas, George; Alvaro, Domenico; Consiglia Bragazzi, Maria; Cardinale, Vincenzo; Carpino, Guido; Gaudio, Eugenio; Chesla, David; Sl, Cottingham; Dubina, Michael; Moiseenko, Fedor; Dhanasekaran, Renumathy; Becker, Karl-Friedrich; Janssen, Klaus‐Peter; Slotta-Huspenina, Julia; H. Abdel‐Rahman, Mohamed; Aziz, Dina; Bell, Sue; M. Cebulla, Colleen; Davis, Amy; Duell, Rebecca; Bradley Elder, J.; Hilty, Joe; Kumar, Bahavna; Lang, James; L. Lehman, Norman; Mandt, Randy; Nguyen, Phuong; Pilarski, Robert; Rai, Karan; Lj, Schoenfield; Senecal, Kelly; Wakely, Paul; Hansen, Paul; Rm, Lechan; Powers, James; Tischler, Arthur; E Grizzle, W; C. Sexton, Katherine; Kastl, Alison; Henderson, Joel; Porten, Sima; Waldmann, Jens; Fassnacht, Martin; L. Asa, Sylvia; Schadendorf, Dirk; Couce, Marta; Graefen, Markus; Huland, Hartwig; Sauter, Guido; Schlomm, Thorsten; Simon, Ronald; Tennstedt, Pierre; Olabode, Oluwole; Nelson, Mark; Bathe, Oliver; R. Carroll, Peter; M. Chan, June; Disaia, Philip; Glenn, Pat; K. Kelley, Robin; N. Landen, Charles; Phillips, Joanna; Prados, Michael; Simko, Jeffry; Smith-McCune, Karen; VandenBerg, Scott; Roggin, Kevin; Fehrenbach, Ashley; Kendler, Ady; Sifri, Suzanne; Steele, Ruth; Jimeno, Antonio; Carey, Francis; Forgie, Ian; Mannelli, Massimo; Carney, Michael; Hernandez, Brenda; Campos, Benito; Herold-Mende, Christel; Jungk, Christin; Unterberg, Andreas; von Deimling, Andreas; Bossler, Aaron; Galbraith, Joseph; Jacobus, Laura; Knudson, Michael; Knutson, Tina; Ma, Deqin; Milhem, Mohammed; Sigmund, R; K. Godwin, Andrew; Madan, Rashna; G. Rosenthal, Howard; Adebamowo, Clement; N. Adebamowo, Sally; Boussioutas, Alex; de Beer, David; Giordano, Thomas; Mes‐Masson, Anne‐Marie; Saad, Fred; Bocklage, Therese; Landrum, Lisa; S. Mannel, R.; Moore, Kathleen; Moxley, Katherine; Rg, Postier; Walker, Joan; Zuna, Rosemary; Feldman, Michael; Valdivieso, Federico; Dhir, Rajiv; Luketich, James; M. Mora Pinero, Edna; Quintero-Aguilo, Mario; Cc, Carlotti; Sebastião dos Santos, José; Kemp, Rafael; Sankarankuty, Ajith; Tirapelli, Daniela; Catto, James; Km, Agnew; Swisher, Elizabeth; Creaney, Jenette; Robinson, Bruce; Simon Shelley, Carl; M. Godwin, Eryn; Kendall, Sara; Shipman, Cassaundra; Bradford, Carol; A. Carey, T.; Haddad, Andrea; Moyer, Jeffey; Peterson, Lisa; Prince, Mark; Rozek, Laura; Wolf, Gregory; Bowman, Rayleen; Fong, K.; Yang, Ian; Rj, Korst; Wg, Rathmell; Leigh Fantacone-Campbell, J.; A. Hooke, Jeffrey; J. Kovatich, Albert; D. Shriver, Craig; Dipersio, John; Drake, Bettina; Govindan, Ramaswamy; HEATH, SHARON; Ley, Timothy; Van Tine, Brian; Westervelt, Peter; A. Rubin, M.; Il Lee, Jung; D. Aredes, Natália; Mariamidze, Armaz; J. Lazar, Alexander; Serody, J.; G. Demicco, Elizabeth; L. Disis, Mary; G. Vincent, Benjamin; Shmulevich, Ilya

doi:10.1016/j.immuni.2018.03.023

Public

The Immune Landscape of Cancer

Published in Immunity • Apr 1, 2018

Authors:

Vésteinn Thórsson

Vésteinn Thorsson

David L. Gibbs

Abstract

We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we identified six immune subtypes-wound healing, IFN-γ dominant, inflammatory, lymphocyte depleted, immunologically quiet, and TGF-β...

Subject

Biology

Immune system

Neuroblastoma RAS viral oncogene homolog

Research Assistant

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