Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal.

Turajlic, Samra; Xu, Hang; Litchfield, Kevin; Rowan, Andrew; Chambers, Tim; I Lopez, Jose; Nicol, David; O'Brien, Tim; Larkin, James; Horswell, Stuart; Stares, Mark; Au, Lewis; Jamal-Hanjani, Mariam; Challacombe, Ben; Chandra, Ashish; Hazell, Steve; Eichler-Jonsson, Claudia; Soultati, Aspasia; Chowdhury, Simon; Rudman, Sarah; Lynch, Joanna; Fernando, Archana; Stamp, Gordon; Nye, Emma; Jabbar, Faiz; Spain, Lavinia; Lall, Sharanpreet; Guarch, Rosa; Falzon, Mary; Proctor, Ian; Pickering, Lisa; Gore, Martin; B K Watkins, Thomas; Ward, Sophia; Stewart, Aengus; DiNatale, Renzo; F Becerra, Maria; Reznik, Ed; J Hsieh, James; A Richmond, Todd; F Mayhew, George; M Hill, Samantha; D McNally, Catherine; Jones, Carol; Rosenbaum, Heidi; Stanislaw, Stacey; L Burgess, Daniel; R Alexander, Nelson; Swanton, Charles; PEACE

doi:10.1016/j.cell.2018.03.057

Public

Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal.

Published in Cell • Apr 19, 2018

NobleIDark:/48914/w1/20260526/8E430597Record on NobleID

Authors:

Samra Turajlic

,

Hang Xu

,

Kevin Litchfield

Abstract

Clear-cell renal cell carcinoma (ccRCC) exhibits a broad range of metastatic phenotypes that have not been systematically studied to date. Here, we analyzed 575 primary and 335 metastatic biopsies across 100 patients with metastatic ccRCC, including two cases sampledat post-mortem. Metastatic compet...

Subject

chromosome instability

cytoreductive nephrectomy

evolution of metastasis

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