Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal

Turajlic, Samra; Xu, Hang; Litchfield, Kevin; Rowan, Andrew; Chambers, Tim; I. López, José; Nicol, David; O’Brien, Tim; Larkin, James; Horswell, Stuart; Stares, Mark; Au, Lewis; Jamal‐Hanjani, Mariam; Challacombe, Ben; Chandra, Ashish; Hazell, Steve; Eichler-Jonsson, Claudia; Soultati, Aspasia; Chowdhury, Simon; Rudman, Sarah; Lynch, Joanna; Fernando, Archana; Stamp, Gordon; Nye, Emma; Jabbar, Faiz; Spain, Lavinia; Lall, Sharanpreet; Guarch, Rosa; Falzon, Mary; Proctor, Ian; Pickering, Lisa; Gore, Martin; B.K. Watkins, Thomas; Ward, Sophia; Stewart, Aengus; G. DiNatale, Renzo; F. Becerra, Maria; Reznik, Ed; J. Hsieh, James; Richmond, Todd; F. Mayhew, George; M. Hill, Samantha; D. McNally, Catherine; Jones, Carol; Rosenbaum, Heidi; Stanislaw, Stacey; L. Burgess, Daniel; R. Alexander, Nelson; Swanton, Charles

doi:10.1016/j.cell.2018.03.057

Public

Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal

Published in Cell • Apr 1, 2018

Authors:

Samra Turajlic

Hang Xu

Kevin Litchfield

Abstract

Clear-cell renal cell carcinoma (ccRCC) exhibits a broad range of metastatic phenotypes that have not been systematically studied to date. Here, we analyzed 575 primary and 335 metastatic biopsies across 100 patients with metastatic ccRCC, including two cases sampledat post-mortem. Metastatic compet...

Subject

Biology

Clear cell renal cell carcinoma

Metastasis

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