Conjugate Addition–Enantioselective Protonation of N -Aryl Glycines to α-Branched 2-Vinylazaarenes via Cooperative Photoredox and Asymmetric Catalysis

Yin, Yanli; Dai, Yating; Jia, Hongshao; Li, Jiangtao; Bu, Liwei; Qiao, Baokun; Zhao, Xiaowei; Jiang, Zhiyong

doi:10.1021/jacs.8b01575

Public

Conjugate Addition–Enantioselective Protonation of N -Aryl Glycines to α-Branched 2-Vinylazaarenes via Cooperative Photoredox and Asymmetric Catalysis

Published in Journal of the American Chemical Society • Apr 10, 2018

Authors:

Yanli Yin

Yating Dai

Hongshao Jia

Abstract

An enantioselective protonation strategy has been successfully applied to the synthesis of chiral α-tertiary azaarenes. With a dual catalytic system involving a chiral phosphoric acid and a dicyanopyrazine-derived chromophore (DPZ) photosensitizer that is mediated by visible light, a variety of α-br...

Subject

Chemistry

Enantioselective synthesis

Protonation

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