Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal

Turajlic, Samra; Xu, Hang; Litchfield, Kevin; Rowan, Andrew; Horswell, Stuart; Chambers, Tim; O’Brien, Tim; I. López, José; B.K. Watkins, Thomas; Nicol, David; Stares, Mark; Challacombe, Ben; Hazell, Steve; Chandra, Ashish; J. Mitchell, Thomas; Au, Lewis; Eichler-Jonsson, Claudia; Jabbar, Faiz; Soultati, Aspasia; Chowdhury, Simon; Rudman, Sarah; Lynch, Joanna; Fernando, Archana; Stamp, Gordon; Nye, Emma; Stewart, Aengus; Wei, Xing; C. Smith, Jonathan; Escudero, Mickael; Huffman, Adam; Matthews, Nik; Elgar, Greg; Phillimore, Ben; Costa, Marta; Begum, Sharmin; Ward, Sophia; Salm, Max; Boeing, Stefan; Fisher, Rosalie; Spain, Lavinia; Navas, Carolina; Grönroos, Eva; Hobor, Sebastijan; Sharma, Sarkhara; Aurangzeb, Ismaeel; Lall, Sharanpreet; Polson, Alexander; Varia, Mary; Horsfield, Catherine; Fotiadis, Nicos; Pickering, Lisa; F. Schwarz, Roland; Silva, Bruno; Herrero, Javier; M. Luscombe, Nick; Jamal‐Hanjani, Mariam; Rosenthal, Rachel; J. Birkbak, Nicolai; A. Wilson, Gareth; Pipek, Orsolya; Ribli, Dezső; Krzystanek, Marcin; Csabai, István; Szállási, Zoltán; Gore, Martin; McGranahan, Nicholas; Van Loo, Peter; J. Campbell, Peter; Larkin, James; Swanton, Charles

doi:10.1016/j.cell.2018.03.043

Public

Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal

Published in Cell • Apr 1, 2018

Authors:

Samra Turajlic

Hang Xu

Kevin Litchfield

Abstract

The evolutionary features of clear-cell renal cell carcinoma (ccRCC) have not been systematically studied to date. We analyzed 1,206 primary tumor regions from 101 patients recruited into the multi-center prospective study, TRACERx Renal. We observe up to 30 driver events per tumor and show that sub...

Subject

Biology

Clear cell renal cell carcinoma

Somatic evolution in cancer

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