Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes

Braidy, Nady; Berg, Jade; P. Clement, James; Khorshidi, Fatemeh; Poljak, Anne; Jayasena, Tharusha; Grant, Ross; S. Sachdev, Perminder

doi:10.1089/ars.2017.7269

Public

Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes

Published in Antioxidants and Redox Signaling • Mar 29, 2018

Authors:

Nady Braidy

Jade Berg

James P. Clement

Abstract

Significance: Nicotinamide adenine dinucleotide (NAD+) is an essential pyridine nucleotide that serves as an essential cofactor and substrate for a number of critical cellular processes involved in oxidative phosphorylation and ATP production, DNA repair, epigenetically modulated gene expression, in...

Subject

NAD+ kinase

Nicotinamide mononucleotide

Nicotinamide adenine dinucleotide

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