Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort

M. Waszak, Sebastian; A. Northcott, Paul; Buchhalter, Ivo; Robinson, Giles; Sutter, Christian; N. Groebner, Susanne; Grund, Kerstin; Brugières, Laurence; Jones, David; W. Pajtler, Kristian; Sorana Morrissy, A.; Kool, Marcel; Sturm, Dominik; Chávez, Lukas; Ernst, Aurélie; Brabetz, Sebastian; Hain, M.; Zichner, Thomas; Segura‐Wang, Maia; Weischenfeldt, Joachim; Rausch, Tobias; R. Mardin, Balca; Zhou, Xin; Baciu, Cristina; Lawerenz, Christian; A. Chan, Jennifer; Varlet, Pascale; Guerrini‐Rousseau, Léa; W. Fults, Daniel; Grajkowska, Wiesława; Hauser, Péter; Jabado, Nada; Ra, Young‐Shin; Zitterbart, Karel; Shringarpure, Suyash; M. De La Vega, Francisco; D. Bustamante, Carlos; Ng, Ho‐Keung; Perry, Arie; J. MacDonald, Tobey; Hernáiz Driever, Pablo; Bendel, Anne; C. Bowers, Daniel; McCowage, Geoffrey; Chintagumpala, Murali; J. Cohn, Richard; Hassall, Tim; Fleischhack, Gudrun; Eggen, Tone; Wesenberg, Finn; Feychting, Maria; Lannering, Birgitta; Schüz, Joachim; Johansen, Christoffer; Veje Andersen, Tina; Röösli, Martin; E. Kuehni, Claudia; A. Grotzer, Michael; Kjærheim, Kristina; Maria Monoranu, Camelia; C. Archer, Tenley; S. Duke, Elizabeth; L. Pomeroy, Scott; Redmond, Shelagh; Frank, Stephan; Sumerauer, David; Scheurlen, Wolfram; Ryzhova, Marina; Milde, Till; P. Kratz, Christian; Samuel, David; Zhang, Jinghui; A. Solomon, David; A. Marra, Marco; Eils, Roland; R. Bartram, Claus; von Hoff, Katja; Rutkowski, Stefan; Ramaswamy, Vijay; J. Gilbertson, Richard; Korshunov, Andrey; D. Taylor, Michael; Lichter, Peter; Malkin, David; Gajjar, Amar; O. Korbel, Jan; M. Pfister, Stefan

doi:10.1016/s1470-2045(18)30242-0

Public

Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort

Published in The Lancet Oncology • May 9, 2018

Authors:

Sebastian M. Waszak

Paul A. Northcott

Ivo Buchhalter

Abstract

BACKGROUND: Medulloblastoma is associated with rare hereditary cancer predisposition syndromes; however, consensus medulloblastoma predisposition genes have not been defined and screening guidelines for genetic counselling and testing for paediatric patients are not available. We aimed to assess and...

Subject

Medulloblastoma

Genetic predisposition

Retrospective cohort study

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