Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target

Dufva, Olli; Kankainen, Matti; Kelkka, Tiina; Sekiguchi, Nodoka; Adnan Awad, Shady; Eldfors, Samuli; Yadav, Bhagwan; Kuusanmäki, Heikki; Malani, Disha; Andersson, Emma; Pietarinen, Paavo; Saikko, Leena; E. Kovanen, Panu; Ojala, Teija; A. Lee, Dean; P. Loughran, Thomas; Nakazawa, Hideyuki; Suzumiya, Junji; Suzuki, Ritsuro; Hyeh Ko, Young; Seog Kim, Won; Chuang, Shih‐Sung; Aittokallio, Tero; C. Chan, Wing; Ohshima, Koichi; Ishida, Fumihiro; Mustjoki, Satu

doi:10.1038/s41467-018-03987-2

Public

Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target

Published in Nature Communications • Apr 13, 2018

Authors:

Olli Dufva

Matti Kankainen

Tiina Kelkka

Abstract

Aggressive natural killer-cell (NK-cell) leukemia (ANKL) is an extremely aggressive malignancy with dismal prognosis and lack of targeted therapies. Here, we elucidate the molecular pathogenesis of ANKL using a combination of genomic and drug sensitivity profiling. We study 14 ANKL patients using wh...

Subject

Cancer research

Biology

Leukemia

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