Microsatellite instability in prostate cancer by PCR or next-generation sequencing

A. Hempelmann, Jennifer; M. Lockwood, Christina; Q. Konnick, Eric; T. Schweizer, Michael; S. Antonarakis, Emmanuel; L. Lotan, Tamara; Montgomery, Bruce; S. Nelson, Peter; Klemfuss, Nola; J. Salipante, Stephen; C. Pritchard, Colin

doi:10.1186/s40425-018-0341-y

Public

Microsatellite instability in prostate cancer by PCR or next-generation sequencing

Published in Journal for ImmunoTherapy of Cancer • Apr 17, 2018

Authors:

Jennifer A. Hempelmann

Christina M. Lockwood

Eric Q. Konnick

Abstract

BACKGROUND: Microsatellite instability (MSI) is now being used as a sole biomarker to guide immunotherapy treatment for men with advanced prostate cancer. Yet current molecular diagnostic tests for MSI have not been evaluated for use in prostate cancer. METHODS: We evaluated two next-generation sequ...

Subject

Microsatellite instability

Prostate cancer

DNA mismatch repair

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