Role of TNF–TNF Receptor 2 Signal in Regulatory T Cells and Its Therapeutic Implications

Tumor Necrosis Factor α (TNFα) is a pleiotropic cytokine which signals through TNF receptor 1 (TNFR1) and TNF receptor 2 (TNFR2). Emerging evidence has demonstrated that TNFR1 is ubiquitously expressed on almost all cells, while TNFR2 exhibits a limited expression, predominantly on regulatory T cell... View More