Dl-3-n-Butylphthalide Inhibits NLRP3 Inflammasome and Mitigates Alzheimer's-Like Pathology <i>via</i> Nrf2-TXNIP-TrX Axis

Wang, Chunyan; Xu, Ye; Wang, Xu; Guo, Chuang; Wang, Tao; Wang, Zhan‐You

doi:10.1089/ars.2017.7440

Public

Dl-3-n-Butylphthalide Inhibits NLRP3 Inflammasome and Mitigates Alzheimer's-Like Pathology via Nrf2-TXNIP-TrX Axis

Published in Antioxidants and Redox Signaling • Mar 29, 2018

Authors:

Chunyan Wang

Ye Xu

Xu Wang

Abstract

AIMS: Oxidative stress and neuroinflammation play important roles in the pathology of Alzheimer's disease (AD). Thioredoxin-interacting protein (TXNIP), an endogenous inhibitor of antioxidant thioredoxin, is suspected to be an important modulator of oxidative stress and inflammation. However, the un...

Subject

TXNIP

Inflammasome

Thioredoxin-Interacting Protein

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