Blockade of MIF–CD74 Signalling on Macrophages and Dendritic Cells Restores the Antitumour Immune Response Against Metastatic Melanoma

R. Figueiredo, Carlos; Azevedo, Ricardo; Mousdell, Sasha; T. Resende-Lara, Pedro; Ireland, Lucy; Santos, Almudena; Girola, Natália; L.O.R. Cunha, Rodrigo; C. Schmid, Michael; Polonelli, Luciano; R. Travassos, Luiz; Mielgo, Ainhoa

doi:10.3389/fimmu.2018.01132

Public

Blockade of MIF–CD74 Signalling on Macrophages and Dendritic Cells Restores the Antitumour Immune Response Against Metastatic Melanoma

Published in Frontiers in Immunology • May 23, 2018

Authors:

Carlos R. Figueiredo

Ricardo Azevedo

Sasha Mousdell

Abstract

Mounting an effective immune response against cancer requires the activation of innate and adaptive immune cells. Metastatic melanoma is the most aggressive form of skin cancer. While immunotherapies have shown a remarkable success in melanoma treatment, patients develop resistance by mechanisms tha...

Subject

Immune system

Cytotoxic T cell

Cancer research

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