Increased vessel perfusion predicts the efficacy of immune checkpoint blockade

Zheng, Xichen; Fang, Zhaoxu; Liu, Xiaomei; Deng, Shengming; Zhou, Pei; Wang, Xuexiang; Zhang, Chenglin; Yin, Rongping; Hu, Haitian; Chen, Xiaolan; Han, Yijie; Zhao, Yun; H. Lin, Steven; Qin, Songbing; Wang, Xiaohua; Y.S. Kim, Betty; Zhou, Penghui; Jiang, Wen; Wu, Qingyu; Huang, Yuhui

doi:10.1172/jci96582

Public

Increased vessel perfusion predicts the efficacy of immune checkpoint blockade

Published in Journal of Clinical Investigation • Apr 16, 2018

Authors:

Xichen Zheng

Zhaoxu Fang

Xiaomei Liu

Abstract

Immune checkpoint blockade (ICB) has demonstrated curative potential in several types of cancer, but only for a small number of patients. Thus, the identification of reliable and noninvasive biomarkers for predicting ICB responsiveness is an urgent unmet need. Here, we show that ICB increased tumor ...

Subject

Blockade

Perfusion

Immune checkpoint

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