The Secretion of miR-200s by a PKCζ/ADAR2 Signaling Axis Promotes Liver Metastasis in Colorectal Cancer

M. Shelton, Phillip; Durán, Ángeles; Nakanishi, Yuki; Reina‐Campos, Miguel; Kasashima, Hiroaki; Lladó, Victoria; Ma, Li; Campos, Alex; García‐Olmo, Damián; García‐Arranz, Mariano; C. Garcı́a-Olmo, Dolores; Olmedillas‐López, Susana; F. Cáceres, Javier; T. Diaz‐Meco, María; Moscat, Jorge

doi:10.1016/j.celrep.2018.03.118

Public

The Secretion of miR-200s by a PKCζ/ADAR2 Signaling Axis Promotes Liver Metastasis in Colorectal Cancer

Published in Cell Reports • Apr 1, 2018

Authors:

Phillip M. Shelton

Ángeles Durán

Yuki Nakanishi

Abstract

Most colorectal cancer (CRC)-related deaths are due to liver metastases. PKCζ is a tumor suppressor in CRC with reduced expression in metastasis. Given the importance of microRNAs (miRNAs) in regulating cellular plasticity, we performed an unbiased screening and identified the miR-200 family as the ...

Subject

Colorectal cancer

Metastasis

Secretion

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